OTULIN Protein, Human (His, GST)

OTULIN Protein, Human (His, GST) is the recombinant human-derived OTULIN, expressed by E. coli , with His, GST labeled tag. ,

OTULIN is a deubiquitinase that specifically cleaves linear ('Met-1'-linked) polyubiquitin chains and plays a critical role in angiogenesis, innate immunity, and the regulation of Wnt and NF-kappa-B signaling pathways. It supports angiogenesis, craniofacial, and neuronal development by modulating canonical Wnt signaling alongside the LUBAC complex. As a negative regulator of NF-kappa-B, OTULIN controls LUBAC activity by removing its autoubiquitination, thus maintaining its function. It also acts as a key suppressor of inflammation and autoimmunity by restricting excessive cytokine secretion and linear ubiquitination. During NOD2 stimulation, OTULIN limits linear ubiquitin chain formation on LUBAC to modulate innate immune responses. by similar: OTULIN primarily functions in maintaining LUBAC complex homeostasis.

Human

E. coli

His;GST

Q96BN8 (M1-L352)

90268

Full Length

Greater than 95% as determined by reducing SDS-PAGE

Solution.

Supplied as a 0.22 μm filtered solution of 50 mM HEPES (pH 7.5), 200mM NaCl, 20% glycerol, 1mM DTT.

<1 EU/μg, determined by LAL method.

Please use rapid thawing with running water to thaw the protein.

Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.