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  4. NPR1/NPRA Protein, Mouse (HEK293, mFc)

NPR1/NPRA Protein, Mouse (HEK293, mFc) is the recombinant mouse-derived NPR1/NPRA protein, expressed by HEK293, with C-mFc tag.

For research use only. We do not sell to patients.

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Description

NPR1/NPRA Protein, Mouse (HEK293, mFc) is the recombinant mouse-derived NPR1/NPRA protein, expressed by HEK293, with C-mFc tag.
Background

NPR1/NPRA is a receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP, which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. It plays an essential role in regulating endothelial cell senescence and vascular aging. Upon activation by ANP or BNP, NPR1/NPRA stimulates the production of cyclic guanosine monophosphate (cGMP), which promotes vascular tone and volume homeostasis by activating protein kinase cGMP-dependent 1/PRKG1 and subsequently PRKAA1, thereby controlling blood pressure and maintaining cardiovascular homeostasis.
Species

Mouse
Source

HEK293
Tag

C-mFc
Accession

NP_032753
Protein Length

Partial
Predicted Molecular Mass
74.9 kDa
Molecular Weight

Approximately 75-105 kDa,based on SDS-PAGE under reducing conditions,due to the glycosylation.
Purity

Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

NPR1/NPRA Protein, Mouse (HEK293, mFc) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Reconstitution Calculator

  • Dilution Calculator

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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NPR1/NPRA Protein, Mouse (HEK293, mFc)
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