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  3. Biotinylated Proteins
  4. NPR1/NPRA Protein, Human (Biotinylated, HEK293, His, Avi)

NPR1/NPRA Protein, Human (Biotinylated, HEK293, His, Avi)

Cat. No.: HY-P704143
Handling Instructions Technical Support

NPR1 Protein, a receptor for atrial natriuretic peptide NPPA/ANP and brain natriuretic peptide NPPB/BNP, initiates signaling cascades with guanylate cyclase activity upon ligand binding. Essential vasoactive hormones, these peptides regulate cardiovascular homeostasis. NPR1 significantly contributes to vascular tone and fluid balance regulation in the cardiovascular system through its role as a receptor for these natriuretic peptides. NPR1/NPRA Protein, Human (Biotinylated, HEK293, His, Avi) is the recombinant human-derived NPR1/NPRA protein, expressed by HEK293, with C-His and C-Avi labeled tag.

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Description

NPR1 Protein, a receptor for atrial natriuretic peptide NPPA/ANP and brain natriuretic peptide NPPB/BNP, initiates signaling cascades with guanylate cyclase activity upon ligand binding. Essential vasoactive hormones, these peptides regulate cardiovascular homeostasis. NPR1 significantly contributes to vascular tone and fluid balance regulation in the cardiovascular system through its role as a receptor for these natriuretic peptides. NPR1/NPRA Protein, Human (Biotinylated, HEK293, His, Avi) is the recombinant human-derived NPR1/NPRA protein, expressed by HEK293, with C-His and C-Avi labeled tag.
Background

The NPR1 Protein serves as a receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP, essential vasoactive hormones that play a pivotal role in cardiovascular homeostasis. Upon binding to these ligands, NPR1 exhibits guanylate cyclase activity, initiating signaling cascades crucial for maintaining cardiovascular balance. Through its role as a receptor for these natriuretic peptides, NPR1 contributes significantly to the regulation of vascular tone and fluid balance in the cardiovascular system.
Species

Human
Source

HEK293
Tag

C-Avi;C-8*His
Accession

P16066 (G33-E473)
Gene ID

4481
Molecular Construction
N-term
NPR1/NPRA (G33-E473)
Accession # P16066
8*His
Avi
C-term
Protein Length

Extracellular Domain
Synonyms
Atrial natriuretic peptide receptor 1; NPR1; NPRA; GC-A; ANPRA; NPR-A
AA Sequence

GNLTVAVVLPLANTSYPWSWARVGPAVELALAQVKARPDLLPGWTVRTVLGSSENALGVCSDTAAPLAAVDLKWEHNPAVFLGPGCVYAAAPVGRFTAHWRVPLLTAGAPALGFGVKDEYALTTRAGPSYAKLGDFVAALHRRLGWERQALMLYAYRPGDEEHCFFLVEGLFMRVRDRLNITVDHLEFAEDDLSHYTRLLRTMPRKGRVIYICSSPDAFRTLMLLALEAGLCGEDYVFFHLDIFGQSLQGGQGPAPRRPWERGDGQDVSARQAFQAAKIITYKDPDNPEYLEFLKQLKHLAYEQFNFTMEDGLVNTIPASFHDGLLLYIQAVTETLAHGGTVTDGENITQRMWNRSFQGVTGYLKIDSSGDRETDFSLWDMDPENGAFRVVLNYNGTSQELVAVSGRKLNWPLGYPPPDIPKCGFDNEDPACNQDHLSTLE

Predicted Molecular Mass
51.8 kDa
Molecular Weight

Approximately 65-80 kDa,based on SDS-PAGE under reducing conditions,due to the glycosylation.
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

NPR1/NPRA Protein, Human (Biotinylated, HEK293, His, Avi) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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