Neurofascin Protein, Human (HEK293, hFc)

Neurofascin Protein, Human (HEK293, hFc) is the recombinant human-derived Neurofascin protein, expressed by HEK293, with C-hFc labeled tag.

NFASC, a cell adhesion and ankyrin-binding protein, is implicated in various neural processes, including neurite extension, axonal guidance, synaptogenesis, myelination, and interactions between neurons and glial cells. It forms a horseshoe-shaped homodimer and is likely a component of the NFASC/NRCAM/ankyrin-G complex. NFASC associates with sodium channel beta-1 (SCN1B) and beta-3 (SCN3B) subunits, indicating its involvement in neuronal excitability and ion channel regulation. Additionally, NFASC interacts with GLDN/gliomedin, emphasizing its role in nodes of Ranvier and myelination. Furthermore, it engages with MYOC, suggesting potential connections to ocular functions or glaucoma. The multifaceted interactions of NFASC underscore its significance in orchestrating diverse cellular processes within the nervous system.

Human

HEK293

C-hFc

O94856-12 (I25-Q939)

23114  [NCBI]

Partial

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.