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  4. Nectin-4 Protein, Cynomolgus (HEK293, hFc)

Nectin-4 Protein, Cynomolgus (HEK293, hFc) is the recombinant cynomolgus-derived Nectin-4 protein, expressed by HEK293, with C-hFc tag.

For research use only. We do not sell to patients.

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Description

Nectin-4 Protein, Cynomolgus (HEK293, hFc) is the recombinant cynomolgus-derived Nectin-4 protein, expressed by HEK293, with C-hFc tag.
Background

The Nectin-4 protein belongs to the nectin family, a group of cell adhesion molecules involved in various cellular processes. Nectin-4 plays a significant role in cell-cell adhesion and is primarily expressed in epithelial tissues. It functions through interactions with other nectin family members and integrins, contributing to the formation and maintenance of cell junctions. Nectin-4 is particularly important in the development and integrity of epithelial tissues, including the skin, lungs, and mammary glands. It is also implicated in cancer progression, as it promotes tumor cell invasion and metastasis. Understanding the role of Nectin-4 in normal physiology and disease pathology can provide valuable insights into potential therapeutic approaches for conditions involving epithelial tissue dysfunction or cancer.
Species

Cynomolgus
Source

HEK293
Tag

C-hFc
Accession

XP_005541277.1 (G32-S349)
Gene ID

102127936
Protein Length

Partial
Synonyms
rCynPoliovirus receptor-related protein 4-like/Nectin-4, His; PVRL4; Nectin-4; Ig superfamily receptor LNIR; Poliovirus receptor-related protein 4; PRR4; LNIR
Predicted Molecular Mass
60.8 kDa
Molecular Weight

Approximately 72.8 kDa,based on SDS-PAGE under reducing conditions.
Purity

Greater than 95% as determined by reducing SDS-PAGE..
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

Nectin-4 Protein, Cynomolgus (HEK293, hFc) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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