METAP2/Methionine aminopeptidase 2 Protein, Human (sf9, C-His)

METAP2/Methionine aminopeptidase 2 Protein, Human (sf9, C-His) is the recombinant human-derived METAP2/Methionine aminopeptidase 2 protein, expressed by Sf9 insect cells, with C-His tag.

METAP2, also known as Methionine Aminopeptidase 2, is a protein with a crucial role in protein synthesis regulation. It cotranslationally removes the N-terminal methionine from nascent proteins, particularly when the second residue in the primary sequence is small and uncharged, such as Met-Ala, Cys, Gly, Pro, Ser, Thr, or Val. This process is essential for proper protein maturation. Furthermore, METAP2 plays a key role in protecting the eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases like EIF2AK2/PKR and EIF2AK1/HCR. By preventing these inhibitory phosphorylation events, METAP2 contributes to the efficient initiation of translation, highlighting its significance in cellular protein synthesis.

Human

Sf9 insect cells

C-His

NP_006829.1 (M1-Y478)

10988

Full Length

MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSAAGEQEPDKESGASVDEVARQLERSALEDKERDEDDEDGDGDGDGATGKKKKKKKKKRGPKVQTDPPSVPICDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVKGGEATRMEEGEVYAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWLDRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRGDDY

Greater than 85% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.