MAdCAM1 Protein, Human (HEK293, Fc)

MAdCAM1 is a cell adhesion leukocyte receptor expressed primarily by mucosal venules and plays a critical role in coordinating lymphocyte trafficking into mucosal tissues, particularly Peyer's patches and intestinal lamina propria. This protein exhibits the ability to bind integrins α-4/β-7 and L-selectin, thereby regulating the passage and retention of leukocytes in the mucosal environment. MAdCAM1 Protein, Human (HEK293, Fc) is the recombinant human-derived MAdCAM1 protein, expressed by HEK293, with C-hFc labeled tag and with N-terminal M.

Mucosal Addressin Cell Adhesion Molecule 1 (MAdCAM1) is a cell adhesion leukocyte receptor expressed on the endothelial cells of mucosal venules, playing a crucial role in directing lymphocyte traffic into mucosal tissues, particularly the Peyer patches and the intestinal lamina propria. MAdCAM1 serves as a binding partner for both integrin alpha-4/beta-7 and L-selectin, thereby regulating the passage and retention of leukocytes in mucosal tissues. The homodimeric structure of MAdCAM1 contributes to its functional role in mediating adhesion between endothelial cells and circulating immune cells. Notably, isoform 2, which lacks the mucin-like domain, may have a specialized function in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding. Understanding the features and interactions of MAdCAM1 provides insights into the intricate mechanisms governing lymphocyte trafficking in mucosal tissues.

Human

HEK293

C-hFc

Q4PKD0 (Q19-Q333)

/

Approximately 70-100 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized powder.

Lyophilized from 0.22 μm filtered solution of PBS, pH7.4 with trehalose as protectant.

<1 EU/μg, determined by LAL method.

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.