Lymphocyte antigen 86/MD-1 Protein, Mouse (HEK293, C-6*His)

Lymphocyte antigen 86/MD-1 Protein, Mouse (HEK293, C-6*His) is the recombinant mouse-derived Lymphocyte antigen 86/MD-1 protein, expressed by HEK293, with C-6*His tag.

The Lymphocyte antigen 86/MD-1 protein emerges as a potential collaborator with CD180 and TLR4, mediating the innate immune response to bacterial lipopolysaccharide (LPS) and influencing cytokine production. Additionally, Lymphocyte antigen 86/MD-1 plays a crucial role in facilitating efficient CD180 cell surface expression. The structural arrangement involves the formation of an M-shaped tetramer, comprising two CD180-LY86 heterodimers. These characteristics underscore the multifaceted nature of Lymphocyte antigen 86/MD-1 in orchestrating immune responses and cellular interactions. Further exploration is essential to unravel the specific molecular mechanisms through which Lymphocyte antigen 86/MD-1 contributes to the intricate dynamics of the innate immune system and its collaboration with CD180 and TLR4 in response to bacterial LPS.

Mouse

HEK293

C-6*His

NP_034875.1 (D20-S162)

17084

Full Length of Mature Protein

DHGSENGWPKHTACNSGGLEVVYQSCDPLQDFGLSIDQCSKQIQSNLNIRFGIILRQDIRKLFLDITLMAKGSSILNYSYPLCEEDQPKFSFCGRRKGEQIYYAGPVNNPGLDVPQGEYQLLLELYNENRATVACANATVTSS

Approximately 23-33 kDa due to the glycosylation.

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  Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized powder.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.