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  4. LRG1 Protein, Cynomolgus (HEK293, His)

LRG1 is a member of the leucine-rich repeat sequence (LRR) family of proteins involved in protein-protein interactions, signal transduction, and cell adhesion and development. LRG1 is involved in promoting neovascularization by causing the switching of transforming growth factor β (TGF-β) signaling in endothelial cells. LRG1 is involved in ovarian cancer progression by activating the FAK/AKT signaling pathway. LRG1 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived LRG1 protein, expressed by HEK293 , with C-His labeled tag.

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Description

LRG1 is a member of the leucine-rich repeat sequence (LRR) family of proteins involved in protein-protein interactions, signal transduction, and cell adhesion and development. LRG1 is involved in promoting neovascularization by causing the switching of transforming growth factor β (TGF-β) signaling in endothelial cells. LRG1 is involved in ovarian cancer progression by activating the FAK/AKT signaling pathway. LRG1 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived LRG1 protein, expressed by HEK293 , with C-His labeled tag.
Background

LRG1 is a member of the leucine-rich repeat sequence (LRR) family of proteins involved in protein-protein interactions, signal transduction, and cell adhesion and development. LRG1 is involved in promoting neovascularization (new blood vessel growth) by causing the switching of transforming growth factor β (TGF-β) signaling in endothelial cells. LRG1 binds to the co-receptor endorphins and promotes signaling through the ALK1-Smad1/5/8 pathway. LRG1 is involved in ovarian cancer progression by activating the FAK/AKT signaling pathway[1][2][3].
Species

Cynomolgus
Source

HEK293
Tag

C-His
Accession

A0A2K5VVA4 (V72-Q383)
Gene ID

102118680
Molecular Construction
N-term
LRG1 (V72-Q383)
Accession # A0A2K5VVA4
His
C-term
Synonyms
Leucine-rich alpha-2-glycoprotein; LRG; LRG1
Molecular Weight

50-60 kDa
Purity

Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

LRG1 Protein, Cynomolgus (HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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