LINGO1 Protein, Human (HEK293, Llama Fc)

LINGO-1 protein is a functional component of the Nogo receptor signaling complex and activates RhoA, thereby inhibiting axonal regeneration through myelin-related factors. It is an important negative regulator of oligodendrocyte differentiation and axonal myelination. LINGO1 Protein, Human (HEK293, Llama Fc) is the recombinant human-derived LINGO1 protein, expressed by HEK293, with C-Llama Fc labeled tag.

LINGO-1 serves as a functional component within the Nogo receptor signaling complex (RTN4R/NGFR), playing a crucial role in RhoA activation and contributing to the inhibition of axonal regeneration caused by myelin-associated factors. This protein is also a key negative regulator of oligodendrocyte differentiation and axonal myelination. In conjunction with RTN4 and RTN4R, LINGO-1 participates in the regulation of neuronal precursor cell motility during cortical development. It forms a homotetramer and engages in a ternary complex with RTN4R/NGFR and RTN4R/TNFRSF19. LINGO-1 further interacts with NGRF and MYT1L, highlighting its multifaceted involvement in neurodevelopmental processes and myelin-associated inhibition.

Human

HEK293

C-Llama Fc

Q96FE5-1 (C42-T561)

84894

Extracellular Domain

Approximately 130-170 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized powder.

Lyophilized from 0.22 μm filtered solution of PBS, pH7.4 with trehalose as protectant.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.