IgE Protein, Mouse (331a.a, HEK293, His)

IgE is an important component of the immunoglobulin chain that coordinates humoral immunity. As a receptor, membrane-bound IgE initiates clonal expansion and B cell differentiation. IgE Protein, Mouse (331a.a, HEK293, His) is the recombinant mouse-derived IgE protein, expressed by HEK293, with C-His labeled tag.

IgE, a crucial component of immunoglobulin heavy chains, plays a pivotal role in the intricate orchestration of humoral immunity. Serving as receptors during the recognition phase, membrane-bound immunoglobulins initiate clonal expansion and B lymphocyte differentiation into plasma cells upon antigen binding. In the effector phase, secreted immunoglobulins facilitate the elimination of bound antigens. The antigen-binding site, marked by remarkable affinity for specific antigens, results from the collaboration between the variable domains of one heavy chain and its associated light chain. Through V-(D)-J rearrangement and subsequent somatic hypermutations, the variable domains undergo affinity maturation, enhancing specificity for particular antigens. Structurally, each immunoglobulin consists of two identical heavy chains and two identical light chains, disulfide-linked. The N-terminal variable regions of the heavy and light chains constitute the antigen-binding sites, while the C-terminal constant regions of the heavy chains interact with immune receptors, driving effector functions. This dynamic interplay defines the versatile and precise role of IgE in orchestrating humoral immune responses.

Mouse

HEK293

C-His

P06336 (V91-S421)

380792

Approximately 45-55 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.