HNRNPA2B1 Protein, Human (His)

Heterogeneous nuclear ribonucleoproteins A2/B1 is an important RNA-binding protein that affects the RNA processing, splicing, transport and stability of many genes. Heterogeneous nuclear ribonucleoproteins A2/B1 is expressed during proliferation and metastasis of various cancer types and promotes such processes. HNRNPA2B1 Protein, Human (His) is the recombinant human-derived HNRNPA2B1 protein, expressed by E. coli , with N-10*His labeled tag.

Heterogeneous nuclear ribonucleoproteins A2/B1 belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). Heterogeneous nuclear ribonucleoproteins A2/B1 is RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). Heterogeneous nuclear ribonucleoproteins A2/B1 is associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. Heterogeneous nuclear ribonucleoproteins A2/B1 has distinct nucleic acid binding properties. Heterogeneous nuclear ribonucleoproteins A2/B1 has two repeats of quasi-RRM domains that bind to RNAs. Heterogeneous nuclear ribonucleoproteins A2/B1 has been described to generate two alternatively spliced transcript variants which encode different isoforms^{[1][2][3][4][5]}.

E. coli

N-10*His

I6L957 (M1-Q249)

/

Full Length

MEREKEQFRKLFIGGLSFETTEESLRNYYEQWGKLTDCVVMRDPASKRSRGFGFVTFSSMAEVDAAMAARPHSIDGRVVEPKRAVAREESGKPGAHVTVKKLFVGGIKEDTEEHHLRDYFEEYGKIDTIEIITDRQSGKKRGFGFVTFDDHDPVDKIVLQKYHTINGHNAEVRKALSRQEMQEDLEVAILEVAPVMEEEEEDMVVEDLDMATRVGATEVVMTTMEEEIMEVEITMILEIITSNLLTTVQ

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.