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  4. HDGFL2 Protein, Human (His, Strep)

HDGFL2 Protein, Human (His, Strep) is the recombinant human-derived HDGFL2, expressed by E. coli , with Strep, His labeled tag.

For research use only. We do not sell to patients.

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Description

HDGFL2 Protein, Human (His, Strep) is the recombinant human-derived HDGFL2, expressed by E. coli , with Strep, His labeled tag.
Background

HDGFL2 acts as an epigenetic regulator of myogenesis in cooperation with DPF3a (isoform 2 of DPF3/BAF45C). It associates with the BAF complex via interaction with DPF3a, and the HDGFL2-DPF3a complex activates myogenic genes by increasing chromatin accessibility through recruitment of SMARCA4/BRG1/BAF190A (the ATPase subunit of the BAF complex) to myogenic gene promoters. Additionally, HDGFL2 promotes the repair of DNA double-strand breaks (DSBs) via the homologous recombination pathway by facilitating the recruitment of the DNA endonuclease RBBP8 to DSBs. It preferentially binds to chromatin regions marked by H3K9me3, H3K27me3, and H3K36me2 and is involved in cellular growth control through the regulation of cyclin D1 expression.
Species

Human
Source

E. coli
Tag

Strep;His
Accession

Q7Z4V5-1 (M1-S93)
Gene ID

84717
Protein Length

Partial
Synonyms
HDGFRP2; HRP2
Predicted Molecular Mass
13.8 kDa
Purity

Greater than 90% as determined by reducing SDS-PAGE
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

HDGFL2 Protein, Human (His, Strep) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Reconstitution Calculator

  • Dilution Calculator

  • Specific Activity Calculator

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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HDGFL2 Protein, Human (His, Strep)
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