GRK6 Protein, Human (sf9, His-GST)

GRK6 selectively phosphorylates activated G protein-coupled receptors, triggering beta-arrestin-mediated desensitization, internalization, and signaling events. It is implicated in desensitizing D2-like dopamine receptors in the striatum and chemokine receptor CXCR4, crucial for CXCL12-induced cell chemotaxis. Additionally, GRK6 phosphorylates rhodopsin (RHO) and the non-GPCR LRP6 during Wnt signaling, as observed in vitro. GRK6 Protein, Human (sf9, His-GST) is the recombinant human-derived GRK6 protein, expressed by Sf9 insect cells , with N-GST, N-His labeled tag.

GRK6 is a protein that selectively phosphorylates activated forms of G protein-coupled receptors, initiating downstream processes such as beta-arrestin-mediated receptor desensitization, internalization, and signaling events crucial for their functional downregulation. It is implicated in the desensitization of D2-like dopamine receptors in the striatum and the chemokine receptor CXCR4, playing a pivotal role in CXCL12-induced cell chemotaxis. Additionally, GRK6 has been shown to phosphorylate rhodopsin (RHO) in vitro and a non G-protein-coupled receptor, LRP6, during Wnt signaling, suggesting its involvement in diverse cellular pathways.

Human

Sf9 insect cells

N-GST;N-His

P43250-2 (M1-R589)

2870  [NCBI]

Approximately 85 kDa

Greater than 90% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.