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  4. GPR15L Protein, Human (His, Myc)

GPR15L Protein, Human (His, Myc) is the recombinant human-derived GPR15L protein, expressed by E. coli, with N-10*His & C-Myc tag.

For research use only. We do not sell to patients.

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Description

GPR15L Protein, Human (His, Myc) is the recombinant human-derived GPR15L protein, expressed by E. coli, with N-10*His & C-Myc tag.
Background

GPR15L is a highly cationic multifunctional protein. It acts as a chemotactic factor mediating lymphocyte recruitment to epithelia through binding and activation of the G-protein coupled receptor GPR15. This protein may function as a tumor suppressor, exhibiting growth inhibitory effects on colon cancer cells in conjunction with SUSD2, including induction of G1 cell cycle arrest. GPR15L potentially regulates keratinocyte proliferation. Additionally, by activating Mas-related G protein-coupled receptors (MRGPRs), it contributes to pruritogenesis through activation of itch-selective sensory neurons and mast cell degranulation. by similar: Studies also suggest its significant roles in immune modulation and sensory nerve regulation.
Species

Human
Source

E. coli
Tag

N-10*His;C-Myc
Accession

Q6UWK7 (K25-V81)
Gene ID

387695
Molecular Construction
N-term
10*His
GPR15L (K25-V81)
Accession # Q6UWK7
Myc
C-term
Protein Length

Full Length of Mature Protein
Synonyms
GPR15L; C10orf99; UNQ1833/PRO3446; Protein GPR15L; Antimicrobial peptide with 57 amino acid residues; AP-57; Antimicrobial peptide-57; Colon-derived SUSD2 binding factor; CSBF; Secreted protein C10orf99
AA Sequence

KRRPAKAWSGRRTRLCCHRVPSPNSTNLKGHHVRLCKPCKLEPEPRLWVVPGALPQV

Predicted Molecular Mass
16 kDa
Molecular Weight

Approximately 16 kDa,based on SDS-PAGE under reducing conditions.
Structure/Form
Monomer
Purity

Greater than 90% as determined by reducing SDS-PAGE.
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

GPR15L Protein, Human (His, Myc) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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GPR15L Protein, Human (His, Myc)
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