Glypican-2/GPC2 Protein, Human (HEK293, Fc)

Glypican-2/GPC2 is a cell surface proteoglycan that interacts with PTN to promote neurite outgrowth. Heparan sulfate of GPC2 binds PTN, releasing PTPRS from CSPG, thereby enabling PTPRS to bind GPC2. Glypican-2/GPC2 Protein, Human (HEK293, Fc) is the recombinant human-derived Glypican-2/GPC2 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Glypican-2/GPC2 Protein, Human (HEK293, Fc) is 530 a.a., with molecular weight of ~35 kDa.

The Glypican-2/GPC2 protein, a cell surface proteoglycan bearing heparan sulfate, is implicated in functions related to the motile behaviors of developing neurons. Through its heparan sulfate, GPC2 interacts with PTN, promoting neurite outgrowth by facilitating the binding of PTN with chondroitin sulfate of proteoglycans. This, in turn, releases PTPRS of chondroitin sulfate proteoglycans (CSPGs), allowing PTPRS to bind with heparan sulfate of GPC2. Additionally, the interaction of GPC2's heparan sulfate chain with MDK is inhibited by heparin followed by chondroitin sulfate E, inducing GPC2 clustering. This clustering, facilitated by the heparan sulfate chain, induces neuronal cell adhesion and neurite outgrowth. The intricate interactions of GPC2 highlight its role in mediating crucial processes during neuronal development and suggest its involvement in modulating cell adhesion and neurite outgrowth through intricate molecular interactions.

Human

HEK293

C-hFc

Q8N158 (S24-S553)

221914  [NCBI]

Approximately 35 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.