2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. TGF-beta Superfamily Neurotrophic Factors
  5. GDNF family
  6. Glial Cell Line-derived Neurotrophic Factor (GDNF)
  7. GDNF Protein, Human (134a.a, HEK293)

GDNF Protein, Human (134a.a, HEK293) is the recombinant human-derived GDNF protein, expressed by HEK293, with tag free tag.

For research use only. We do not sell to patients.

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Description

GDNF Protein, Human (134a.a, HEK293) is the recombinant human-derived GDNF protein, expressed by HEK293, with tag free tag.
Background

GDNF is a neurotrophic factor that enhances the survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. It functions by binding to its coreceptor, GFRA1, leading to autophosphorylation and activation of the RET receptor. Additionally, GDNF is involved in the development of the neural crest. by similar: This functional description is supported by multiple research studies.
Species

Human
Source

HEK293
Tag

Tag Free
Accession

P39905-1 (S78-I211)
Gene ID

2668
Molecular Construction
N-term
GDNF (S78-I211)
Accession # P39905-1
C-term
Protein Length

Full Length of GDNF
Synonyms
Glial cell line-derived neurotrophic factor; ATF; HFB1-GDNF; HGDNF; HSCR3
Predicted Molecular Mass
15.1 kDa
Molecular Weight

Approximately 15-22 kDa,based on SDS-PAGE under reducing conditions,due to the glycosylation.
Glycosylation
Yes
Purity

Greater than 90% as determined by reducing SDS-PAGE.
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

GDNF Protein, Human (134a.a, HEK293) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Reconstitution Calculator

  • Dilution Calculator

  • Specific Activity Calculator

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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GDNF Protein, Human (134a.a, HEK293)
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