GDNF Protein, Human (134a.a, HEK293)

GDNF Protein, Human (134a.a, HEK293) is the recombinant human-derived GDNF protein, expressed by HEK293, with tag free tag.

GDNF is a neurotrophic factor that enhances the survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. It functions by binding to its coreceptor, GFRA1, leading to autophosphorylation and activation of the RET receptor. Additionally, GDNF is involved in the development of the neural crest. by similar: This functional description is supported by multiple research studies.

Human

HEK293

Tag Free

P39905-1 (S78-I211)

2668

Full Length of GDNF

Approximately 15-22 kDa,based on SDS-PAGE under reducing conditions,due to the glycosylation.

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized powder.

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Lyophilized powder.