GAS6 Protein, Human (208a.a, HEK293, His)

The GAS6 protein is a ligand for AXL, TYRO3 and MER receptors and affects a variety of cellular processes. GAS6/AXL signaling promotes endothelial cell survival, aids cytokine signaling in natural killer cell development, supports liver regeneration, affects gonadotropin-releasing hormone neuron survival and migration, modulates platelet activation, and regulates thrombotic responses. GAS6 Protein, Human (208a.a, HEK293, His) is the recombinant human-derived GAS6 protein, expressed by HEK293, with N-His labeled tag.

GAS6, a ligand for tyrosine-protein kinase receptors AXL, TYRO3, and MER, is implicated in diverse cellular processes including cell growth, survival, adhesion, and migration. GAS6/AXL signaling contributes to endothelial cell survival under acidic conditions by preventing apoptosis, facilitates optimal cytokine signaling during human natural killer cell development, plays a role in hepatic regeneration, influences gonadotropin-releasing hormone neuron survival and migration, regulates platelet activation, and modulates thrombotic responses. Additionally, in microbial infections, GAS6 can act as a bridge between virus envelope phosphatidylserine and the TAM receptor tyrosine kinase Axl, facilitating viral entry through apoptotic mimicry. This unique function extends to its involvement in the entry processes of diverse viruses, including Dengue, Vaccinia, ebolavirus, and marburgvirus, highlighting the multifaceted roles of GAS6 in cellular and infectious contexts.

Human

HEK293

N-His

Q14393-2 (F471-A678)

2621

Approximately 26-27 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized powder.

Lyophilized from 0.22 μm filtered solution of PBS, pH7.4 with trehalose as protectant.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.