Galectin 1 Protein, Mouse (HEK293, hFc)

Galectin-1/LGALS1 protein is a β-galactoside-binding lectin that regulates apoptosis, cell proliferation, and differentiation by inhibiting CD45 protein phosphatase. It prevents Lyn kinase dephosphorylation, induces T cell apoptosis as a homodimer, and interacts with CD2, CD3, CD4, CD6, CD7, CD43, ALCAM and CD45. Galectin 1 Protein, Mouse (HEK293, hFc) is the recombinant mouse-derived Galectin 1 protein, expressed by HEK293, with N-hFc labeled tag.

Galectin-1/LGALS1 Protein functions as a versatile lectin with a high affinity for beta-galactoside and a diverse range of complex carbohydrates. Its pivotal role extends to the regulation of apoptosis, cell proliferation, and cell differentiation. Notably, Galectin-1/LGALS1 acts as an inhibitor of CD45 protein phosphatase activity, thereby preventing the dephosphorylation of Lyn kinase. Furthermore, it serves as a potent inducer of T-cell apoptosis and exists as a homodimer. The protein engages in various interactions, binding to LGALS3BP and interacting with cell surface proteins such as CD2, CD3, CD4, CD6, CD7, CD43, ALCAM, and CD45. Galectin-1/LGALS1 also forms associations with laminin through poly-N-acetyllactosamine binding and interacts with SUSD2. A noteworthy interaction occurs with the cargo receptor TMED10, facilitating translocation from the cytoplasm into the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) and subsequent secretion.

Mouse

HEK293

N-hFc

P16045 (A2-E135)

16852

Full Length of Mature Protein

Approximately 45-52 kDa,based on SDS-PAGE under reducing conditions,due to the glycosylation.

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.