Fas/CD95 Protein, Cynomolgus (HEK293, hFc)

Fas/CD95 Protein, Cynomolgus (HEK293, hFc) is the recombinant cynomolgus-derived Fas/CD95 protein, expressed by HEK293, with C-hFc tag.

Fas, also known as CD95, serves as a receptor for TNFSF6/FASLG, initiating a cascade of apoptotic events crucial for programmed cell death. The adapter molecule FADD facilitates the recruitment of caspase-8 to the activated receptor, forming the death-inducing signaling complex (DISC) and initiating the cascade of caspases that mediate apoptosis. FAS-mediated apoptosis is implicated in peripheral tolerance induction and the antigen-stimulated suicide of mature T-cells. Additionally, secreted isoforms 2 to 6 of Fas have been identified, which function to block apoptosis in vitro. Fas engages in diverse protein interactions, including DAXX, HIPK3, RIPK1, FAIM2, BABAM2, FEM1B, FADD, NOL3, and CALM, forming a complex network that regulates cell death signaling. The interaction with various molecules highlights the multifaceted roles of Fas in cellular processes, emphasizing its significance in immune regulation and apoptosis modulation.

Cynomolgus

HEK293

C-hFc

F6V1W6 (M1-N173)

574332

Partial

Approximately 47-57 kDa,based on SDS-PAGE under reducing conditions.

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.