2. Recombinant Proteins
  3. Enzymes & Regulators
  4. Transferases (EC 2)
  5. EHMT1 Protein, Human (His)

EHMT1 Protein, Human (His) is the recombinant human-derived EHMT1, expressed by E. coli , with His labeled tag.

For research use only. We do not sell to patients.

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Description

EHMT1 Protein, Human (His) is the recombinant human-derived EHMT1, expressed by E. coli , with His labeled tag.
Background

EHMT1 is a histone methyltransferase that specifically mono- and dimethylates lysine 9 of histone H3 (H3K9me1 and H3K9me2) in euchromatin. H3K9me serves as an epigenetic mark for transcriptional repression by recruiting HP1 proteins to methylated histones. It also weakly methylates lysine 27 of histone H3 (H3K27me) and is involved in DNA methylation (with its histone methyltransferase activity functioning independently of DNA methylation). Likely targeted to histone H3 by DNA-binding proteins such as E2F6, MGA, MAX, or DP1, it contributes to silencing MYC- and E2F-responsive genes during G0 phase, implicating a role in G0/G1 transition regulation. Beyond histone methylation, EHMT1 dimethylates non-histone proteins (e.g., lysine 373 of p53/TP53) and represses mitochondrial function-related genes, potentially through promoter occupancy in concert with BAZ2B (by similarity).
Species

Human
Source

E. coli
Tag

His
Accession

Q9H9B1-1 (N765-A999)
Gene ID

79813
Protein Length

Partial
Synonyms
EUHMTASE1; GLP; KIAA1876; KMT1D
Predicted Molecular Mass
27.9 kDa
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

EHMT1 Protein, Human (His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Reconstitution Calculator

  • Dilution Calculator

  • Specific Activity Calculator

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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EHMT1 Protein, Human (His)
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