EGFL6 Protein, Mouse (HEK293, Fc)

The EGFL6 protein is a key player in hair follicle morphogenesis and may influence cell dynamics through binding to integrin α-8/β-1. This interaction is shown to play a key role in the complex process that controls hair follicle formation. EGFL6 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived EGFL6 protein, expressed by HEK293 , with C-hFc labeled tag.

The EGFL6 protein emerges as a pivotal participant in hair follicle morphogenesis, potentially exerting its influence by binding to integrin alpha-8/beta-1. This interaction suggests a key role in the intricate processes governing cellular dynamics during hair follicle formation. Moreover, EGFL6 is implicated in promoting matrix assembly, underscoring its essential contribution to the structural organization crucial for the development and maintenance of hair follicles. The dual functionality of EGFL6, involving integrin binding and matrix assembly, highlights its multifaceted role in orchestrating cellular events and structural processes integral to hair follicle morphogenesis. Further investigation is warranted to unravel the specific mechanisms through which EGFL6 modulates these processes, deepening our understanding of its significance in hair follicle development.

Measured by the ability of the immobilized protein to support the adhesion of NIH-3T3 mouse embryonic fibroblast cells. Recombinant Mouse EGF-L6 immobilized at 2 µg/mL, 100 µL/well, 78.85% cells will adhere specifically after 30 minutes at 37°C.

Mouse

HEK293

C-hFc

Q9JJZ5/NP_062270.1 (T287-G550)

54156  [NCBI]

Partial

TMKKKVKLKMVTPRPASTRVPKVNLPYSSEEGVSRGRNYDGEQKKKEEGKRERLEEEKGEKTLRNEVEQERTLRGDVFSPKVNEAEDLDLVYVQRKELNSKLKHKDLNISVDCSFDLGVCDWKQDREDDFDWHPADRDNDVGYYMAVPALAGHKKNIGRLKLLLPNLTPQSNFCLLFDYRLAGDKVGKLRVFVKNSNNALAWEETKNEDGRWRTGKIQLYQGIDTTKSVIFEAERGKGKTGEIAVDGVLLVSGLCPDDFLSVEG

Approximately 66-73 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.

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  Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized powder

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.