DR6/TNFRSF21 Protein, Human (HEK293, His)

DR6/TNFRSF21 protein is the core protein of apoptosis and can activate NF-kappa-B, BAX-mediated apoptosis and mitochondrial cytochrome c release.In neuronal apoptosis, it is critical for amyloid peptide-triggered cell body death and axonal pruning.DR6/TNFRSF21 Protein, Human (HEK293, His) is the recombinant human-derived DR6/TNFRSF21 protein, expressed by HEK293 , with C-6*His labeled tag.

The DR6/TNFRSF21 Protein has multiple roles in promoting apoptosis, including activation of NF-kappa-B and apoptosis mediated by BAX and cytochrome c release from the mitochondria. It is involved in neuronal apoptosis triggered by amyloid peptides, contributing to both cell body death and axonal pruning. Additionally, it negatively regulates oligodendrocyte survival, maturation, and myelination. The protein also plays a crucial role in T-cell signaling, adaptive immune response, and the regulation of T-cell differentiation and proliferation. It inhibits T-cell responses and the release of cytokines, as well as the production of IgG, IgM, and IgM in response to antigens. Furthermore, it acts as a regulator of pyroptosis, recruiting CASP8 upon reactive oxygen species (ROS) stimulation and oxidation, leading to GSDMC activation. The DR6/TNFRSF21 Protein interacts with NGFR, CASP8, and N-APP and associates with TRADD.

Human

HEK293

C-6*His

O75509 (Q42-L350)

27242  [NCBI]

Extracellular Domain

QPEQKASNLIGTYRHVDRATGQVLTCDKCPAGTYVSEHCTNTSLRVCSSCPVGTFTRHENGIEKCHDCSQPCPWPMIEKLPCAALTDRECTCPPGMFQSNATCAPHTVCPVGWGVRKKGTETEDVRCKQCARGTFSDVPSSVMKCKAYTDCLSQNLVVIKPGTKETDNVCGTLPSFSSSTSPSPGTAIFPRPEHMETHEVPSSTYVPKGMNSTESNSSASVRPKVLSSIQEGTVPDNTSSARGKEDVNKTLPNLQVVNHQQGPHHRHILKLLPSMEATGGEKSSTPIKGPKRGHPRQNLHKHFDINEHL

Approximately 58 kDa

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized powder

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.