CTLA-4 Protein, Rabbit (HEK293, Fc)

CTLA-4 protein is a critical inhibitory receptor that functions as a major negative regulator of T-cell responses. It has a stronger affinity for CD80 and CD86 than CD28, allowing it to effectively dampen T-cell activation and contribute to immune response regulation. CTLA-4 forms a homodimer and interacts with CD80/B7-1, CD86/B7.2, and ICOSLG, highlighting its multifaceted role in immune checkpoints. CTLA-4 Protein, Rabbit (HEK293, Fc) is the recombinant Rabbit-derived CTLA-4 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CTLA-4 Protein, Rabbit (HEK293, Fc) is 126 a.a., with molecular weight of 50-55 kDa.

CTLA-4 protein operates as a pivotal inhibitory receptor, serving as a primary negative regulator of T-cell responses. The distinctive feature of CTLA-4 lies in its significantly stronger affinity for its natural B7 family ligands, CD80 and CD86, in comparison to the affinity of their corresponding stimulatory coreceptor CD28. This heightened binding capability enables CTLA-4 to act as a potent modulator, dampening T-cell activation and contributing to the intricate regulatory network of immune responses. Structurally, CTLA-4 forms a homodimer linked by disulfide bonds and interacts with CD80/B7-1 and CD86/B7.2, crucial players in regulating T-cell activation. Additionally, CTLA-4 engages with ICOSLG, further highlighting its multifaceted role in orchestrating immune checkpoints.

Rabbit

HEK293

C-hFc

P42072 (K36-D161)

100009412  [NCBI]

50-55 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.