CTLA-4 Protein, Cynomolgus (Biotinylated, HEK293, His-Avi)

CTLA-4 Protein, a pivotal inhibitory receptor, is a primary negative modulator of T-cell responses in immune regulation. Its distinctive property lies in significantly higher affinity for B7 ligands (CD80/CD86) than the stimulatory coreceptor CD28. Outcompeting CD28 for ligand engagement, CTLA-4 exerts a suppressive influence on T-cell activation, mitigating excessive immune responses in the intricate landscape of immune regulation. CTLA-4 Protein, Cynomolgus/Rhesus macaque (Biotinylated, HEK293, His-Avi) is the recombinant cynomolgus, Rhesus Macaque-derived CTLA-4 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of CTLA-4 Protein, Cynomolgus/Rhesus macaque (Biotinylated, HEK293, His-Avi) is 124 a.a., with molecular weight of 20-26 kDa.

CTLA-4, a pivotal inhibitory receptor, assumes a paramount role as a primary negative modulator of T-cell responses within the intricate landscape of immune regulation. This regulatory function hinges on the distinctive property of CTLA-4 to exhibit significantly higher affinity for its natural B7 family ligands, CD80 and CD86, in comparison to the cognate stimulatory coreceptor CD28. This pronounced difference in binding affinity underscores the capacity of CTLA-4 to outcompete CD28 for ligand engagement, thereby exerting a suppressive influence on T-cell activation and mitigating excessive immune responses.

Cynomolgus; Rhesus Macaque

HEK293

C-Avi;C-His

G7PL88 (A37-S160)

102115124  [NCBI]

20-26 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.