CLEC14A Protein, Human (HEK293, His)

CLEC14A is a type I transmembrane protein belonging to the C-type lectin superfamily that mediates intercellular adhesion, inflammatory response, and apoptosis. CLEC14A is upregulated in hepatocellular carcinoma and may serve as a potential diagnostic biomarker. CLEC14A Protein, Human (HEK293, His) is the recombinant human-derived CLEC14A protein, expressed by HEK293 , with C-His labeled tag.

The C-type agglutinin-like receptors (CLECs) family consists of different transmembrane pattern recognition receptors. CLECs play a key role in regulating cancer cell growth, maintaining hemostasis and promoting cell communication. CLEC14A is a type I transmembrane protein belonging to the C-type lectin superfamily that mediates intercellular adhesion, inflammatory response, and apoptosis. CLEC14A contributes to the germination and stability of blood vessels during angiogenesis and the formation of normal lymphatic sacs and blood vessels by regulating the expression levels and signaling of VEGFR-3 and VEGFR-2. CLEC14A is upregulated in hepatocellular carcinoma and may serve as a potential diagnostic biomarker^[1][2][3].

Human

HEK293

C-His

Q86T13 (E22-A397)

161198  [NCBI]

70-80 kDa

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized powder.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.