2. Recombinant Proteins
  3. Enzymes & Regulators
  4. CKS2 Protein, Human

CKS2 protein intricately binds to TEK/TIE2 to regulate ANGPT1 signaling. Its binding induces receptor tyrosine phosphorylation, affecting downstream cellular responses. CKS2 Protein, Human is the recombinant human-derived CKS2 protein, expressed by E. coli , with tag free.

For research use only. We do not sell to patients.

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Description

CKS2 protein intricately binds to TEK/TIE2 to regulate ANGPT1 signaling. Its binding induces receptor tyrosine phosphorylation, affecting downstream cellular responses. CKS2 Protein, Human is the recombinant human-derived CKS2 protein, expressed by E. coli , with tag free.
Background

Angiopoietin-4 (ANGPT4) intricately engages with TEK/TIE2, exerting regulatory control over ANGPT1 signaling. Its binding to TEK/TIE2 has the potential to induce tyrosine phosphorylation of the receptor, thereby influencing downstream cellular responses. ANGPT4 plays a crucial role in fostering endothelial cell survival, enhancing cell migration, and promoting angiogenesis, contributing to the intricate orchestration of vascular processes. Structurally, ANGPT4 exists as a homodimer, with disulfide linkages ensuring molecular stability. The direct interaction with TEK/TIE2 underscores the significance of ANGPT4 in modulating key signaling pathways associated with vascular homeostasis and angiogenic responses.
Species

Human
Source

E. coli
Tag

Tag Free
Accession

P33552 (M1-K79)
Gene ID

1164
Molecular Construction
N-term
CKS2 (M1-K79)
Accession # P33552
C-term
Protein Length

Full Length
Synonyms
CKS2; Cyclin-dependent kinases regulatory subunit 2; CKS-2
Purity

Greater than 90% as determined by reducing SDS-PAGE.
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

CKS2 Protein, Human Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Reconstitution Calculator

  • Dilution Calculator

  • Specific Activity Calculator

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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CKS2 Protein, Human
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