CHL1 Protein, Mouse (HEK293)

CHL1 Protein, Mouse (HEK293) is the recombinant mouse-derived CHL1 protein, expressed by HEK293, with tag free.

CHL1 is an extracellular matrix and cell adhesion protein involved in nervous system development and synaptic plasticity. Both soluble and membranous forms promote neurite outgrowth in cerebellar and hippocampal neurons while suppressing neuronal cell death. It contributes to pyramidal neuron positioning and regulates interneuron numbers and GABAergic synapse efficacy. CHL1 may also modulate cell migration during nerve regeneration and cortical development. Additionally, it enhances integrin-dependent cell migration toward extracellular matrix proteins. By similarity, it recruits ANK3 to the plasma membrane.

Measured in a cell proliferation assay using SH-SY5Y cells. The ED₅₀ for this effect is 0.369 μg/mL, corresponding to a specific activity is 2710.027 Unit/mg,

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  Measured in a cell proliferation assay using SH-SY5Y cells. The ED₅₀ for this effect is 0.369 μg/mL, corresponding to a specific activity is 2710.027 Unit/mg,

Mouse

HEK293

Tag Free

XP_017176866 (A25-Q1027)

12661  [NCBI]

Partial

113-123 kDa

Greater than 90% as determined by reducing SDS-PAGE.

Solution.

Supplied as a 0.22 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.