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  4. CERS6 Protein, Human (HEK293, His, Strep)

CERS6 Protein, Human (HEK293, His, Strep) is the recombinant human-derived CERS6, expressed by HEK293 , with Strep, His labeled tag. ,

For research use only. We do not sell to patients.

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Description

CERS6 Protein, Human (HEK293, His, Strep) is the recombinant human-derived CERS6, expressed by HEK293 , with Strep, His labeled tag. ,
Background

CERS6 is a ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, exhibiting high selectivity for palmitoyl-CoA (hexadecanoyl-CoA; C16:0-CoA). It can also utilize other acyl donors, though with reduced efficiency (By similarity). In de novo synthesis and salvage pathways, CERS6 N-acylates sphinganine and sphingosine bases to produce dihydroceramides and ceramides, respectively. Ceramides generated by CERS6 are involved in inflammatory responses (By similarity) and regulate metabolism and hepatic lipid accumulation (By similarity). Under high-fat diet conditions, CERS6-derived palmitoyl- (C16:0-) ceramides bind to the mitochondrial fission factor MFF, promoting mitochondrial fragmentation and contributing to obesity development (By similarity).
Species

Human
Source

HEK293
Tag

Strep;His
Accession

Q6ZMG9-1 (M1-D384end)
Gene ID

253782
Protein Length

Full Length of Isoform-1
Synonyms
LASS6
Predicted Molecular Mass
49 kDa
Glycosylation
Yes
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

CERS6 Protein, Human (HEK293, His, Strep) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Reconstitution Calculator

  • Dilution Calculator

  • Specific Activity Calculator

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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CERS6 Protein, Human (HEK293, His, Strep)
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