CD4 Protein, Rhesus Macaque (HEK293, His)

CD4 Protein forms surface dimers, interacts with LCK and PTK2/FAK1, and binds to P4HB/PDI. It induces CD4-dependent signaling with IL16. CD4 interacts with MHCII alpha and beta chains, increasing TCR affinity. Oligomerization of CD4 is necessary for stable MHCII binding and T cell-APC adhesion. CD4 Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived CD4 protein, expressed by HEK293 , with C-His labeled tag.

CD4 protein forms disulfide-linked homodimers at the cell surface and interacts with various proteins, including LCK, PTK2/FAK1, and P4HB/PDI. It also engages with IL16, leading to CD4-dependent signaling in lymphocytes. Furthermore, CD4 interacts with MHCII alpha and beta chains, enhancing the affinity of the T-cell receptor (TCR) for peptide-MHCII. The oligomerization of CD4, particularly via Ig-like C2-type domains 2 and 3, is crucial for stable binding to MHCII and facilitates adhesion between T cells and antigen-presenting cells (APCs).

Rhesus Macaque

HEK293

C-His

G7N5T8 (K26-W390)

/

Partial

45-52 kDa

Greater than 95% as determined by Tris-Bis PAGE.

<1 EU/μg, determined by LAL method.