CD2 Protein, Human (Biotinylated, HEK293, His-Avi)

CD2 Protein mediates T-cell adhesion to other cell types by interacting with CD58 (LFA-3) and CD48/BCM1. Implicated in T-cell triggering, its cytoplasmic domain has signaling functions. CD2 also interacts with CD2AP and PSTPIP1. Moreover, its interaction with FCGR3A modulates NK cell activation and cytotoxicity. CD2 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived CD2 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of CD2 Protein, Human (Biotinylated, HEK293, His-Avi) is 185 a.a., with molecular weight of 35-43 kDa.

CD2 is a cell surface glycoprotein that plays a crucial role in mediating adhesion between T-cells and various cell types through interactions with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1. Beyond its adhesive function, CD2 is implicated in triggering T-cell responses, with its cytoplasmic domain playing a role in signaling pathways. The protein interacts with CD48, CD58 (LFA-3), CD2AP, and PSTPIP1, contributing to a complex network of molecular interactions. Additionally, the interaction between CD2 and FCGR3A modulates NK cell activation and cytotoxicity, highlighting its diverse involvement in immune cell functions.

Human

HEK293

C-Avi;C-His

AAH33583 (K25-D209)

914  [NCBI]

35-43 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.