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  4. CBFA2T3 Protein, Human (His, Strep)

CBFA2T3 Protein, Human (His, Strep) is the recombinant human-derived CBFA2T3, expressed by E. coli , with Strep, His labeled tag.

For research use only. We do not sell to patients.

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Description

CBFA2T3 Protein, Human (His, Strep) is the recombinant human-derived CBFA2T3, expressed by E. coli , with Strep, His labeled tag.
Background

CBFA2T3 is a transcriptional corepressor that facilitates gene silencing by associating with DNA-binding transcription factors and recruiting other corepressors or histone-modifying enzymes (e.g., EGLN1). It represses MMP7 expression in a ZBTB33-dependent manner and promotes HIF1A prolyl hydroxylation-dependent ubiquitination and degradation via interaction with EGLN1, thereby reducing HIF1A protein stability. Additionally, CBFA2T3 downregulates glycolytic genes (e.g., PFKFB3, PFKFB4, PDK1, PFKP, LDHA, HK1)—direct targets of HIF1A—to suppress glycolysis and enhance mitochondrial respiration. It regulates erythroid progenitor proliferation/differentiation by inhibiting TAL1 target genes (by similar) and contributes to granulocyte differentiation.
Species

Human
Source

E. coli
Tag

Strep;His
Accession

O75081-1 (G170-S276)
Gene ID

863
Protein Length

Partial
Synonyms
MTG16; MTGR2; ZMYND4
Predicted Molecular Mass
15 kDa
Purity

Greater than 90% as determined by reducing SDS-PAGE
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

CBFA2T3 Protein, Human (His, Strep) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Reconstitution Calculator

  • Dilution Calculator

  • Specific Activity Calculator

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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CBFA2T3 Protein, Human (His, Strep)
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