2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. TGF-beta Superfamily
  5. BMP Receptor
  6. BMP Type II Receptor (BMPR2)
  7. BMPR-II Protein, Human (HEK293, hFc)

BMPR-II Protein, Human (HEK293, hFc) is the recombinant human-derived BMPR-II protein, expressed by HEK293, with C-hFc tag.

For research use only. We do not sell to patients.

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Description

BMPR-II Protein, Human (HEK293, hFc) is the recombinant human-derived BMPR-II protein, expressed by HEK293, with C-hFc tag.
Background

BMPR2 is a type II transmembrane serine/threonine kinase receptor that forms a complex with two type II and two type I receptors upon ligand binding. Type II receptors phosphorylate and activate type I receptors, which then autophosphorylate and recruit SMAD transcriptional regulators. It also mediates signaling via the p38MAPK cascade. BMPR2 binds to BMP7 and BMP2 (less efficiently to BMP4), with weak binding enhanced by the presence of BMP type I receptors. It mediates adipogenesis induction by GDF6 and promotes signaling through interaction with activin A/INHBA.
Species

Human
Source

HEK293
Tag

C-hFc
Accession

Q13873-1 (S27-T150)
Gene ID

659
Molecular Construction
N-term
BMPR-II (Ser27-Thr150)
Accession # Q13873-1
hFc
C-term
Protein Length

Extracellular Domain
Synonyms
BMPR-2; BMPR-II; PPH1
Predicted Molecular Mass
39.8 kDa
Molecular Weight

Approximately 55-70 kDa,based on SDS-PAGE under reducing conditions,due to the glycosylation.
Glycosylation
Yes
Purity

Greater than 95% as determined by Tris-Bis PAGE.
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

BMPR-II Protein, Human (HEK293, hFc) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Reconstitution Calculator

  • Dilution Calculator

  • Specific Activity Calculator

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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