beta-Catenin Protein, Human (His)

Beta-Catenin protein is an important component of the canonical Wnt pathway and regulates cellular processes. In the absence of Wnt, it complexes with AXIN1, AXIN2, APC, CSNK1A1, and GSK3B to promote CTNNB1 phosphorylation and degradation. beta-Catenin Protein, Human (His) is the recombinant human-derived beta-Catenin protein, expressed by E. coli, with N-His labeled tag.

Beta-Catenin protein functions as a key downstream component in the canonical Wnt signaling pathway, regulating various cellular processes. In the absence of Wnt, it forms a complex with AXIN1, AXIN2, APC, CSNK1A1, and GSK3B, promoting phosphorylation and ubiquitination of CTNNB1 for subsequent degradation. Upon Wnt ligand binding, CTNNB1 accumulates in the nucleus, acting as a coactivator for transcription factors of the TCF/LEF family to activate Wnt-responsive genes. Beyond its role in Wnt signaling, beta-Catenin is involved in cell adhesion, acting as part of an E-cadherin:catenin adhesion complex. It plays a role in regulating centrosome cohesion, CDK2/PTPN6/CTNNB1/CEACAM1-mediated insulin internalization, and promotes neurogenesis. Additionally, beta-Catenin interacts with various proteins, including AXIN1, SRC, TCF7L2, and others, highlighting its involvement in intricate molecular networks governing diverse cellular functions. The dynamic interactions and dual roles of beta-Catenin underscore its significance in cellular homeostasis and signaling cascades.

Human

E. coli

N-His

P35222 (N138-E686)

1499

Approximately 60-65 kDa,based on SDS-PAGE under reducing conditions.

Greater than 95% as determined by reducing SDS-PAGE..

<1 EU/μg, determined by LAL method.