BAFF/TNFSF13B Trimer Protein, Human (Biotinylated, HEK293, His-Avi)

BAFF/TNFSF13B protein is a cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA, forming a key ligand-receptor pathway together with TNFSF13/APRIL. These interactions play a crucial role in stimulating B-cell and T-cell function and regulating humoral immunity. BAFF/TNFSF13B Trimer Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived BAFF/TNFSF13B protein, expressed by HEK293 , with N-His, N-Avi labeled tag.

BAFF/TNFSF13B protein, a cytokine, binds to TNFRSF13B/TACI and TNFRSF17/BCMA, forming a key ligand-receptor pathway alongside TNFSF13/APRIL. Together, these interactions play a crucial role in stimulating B- and T-cell function and regulating humoral immunity. Notably, a third B-cell-specific receptor, BAFFR/BR3, is involved in promoting the survival of mature B-cells and facilitating the B-cell response. This intricate network underscores the significance of BAFF/TNFSF13B in orchestrating immune responses. Additionally, isoform 2 of BAFF/TNFSF13B appears to exert a regulatory role by inhibiting the secretion and bioactivity of isoform 1. The dynamic interplay between these isoforms further contributes to the nuanced control of BAFF/TNFSF13B-mediated immune processes.

Human

HEK293

N-Avi;N-8*His

Q9Y275-1 (T141-L285)

10673  [NCBI]

Partial

TVTQDCLQLIADSETPTIQKGSYTFVPWLLSFKRGSALEEKENKILVKETGYFFIYGQVLYTDKTYAMGHLIQRKKVHVFGDELSLVTLFRCIQNMPETLPNNSCYSAGIAKLEEGDELQLAIPRENAQISLDGDVTFFGALKLL

Approximately 55-68 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.

Greater than 95% as determined by Tris-Bis PAGE.

<1 EU/μg, determined by LAL method.