B7-H2/ICOSLG Protein, Cynomolgus (HEK293, Fc)

B7-H2 is the ligand of Inducible Costimulator, was a ligand for CD28 and CTLA-4 in human, whereas these interactions were not conserved in mouse. B7-H2 interacted with CD28 in a non-overlapping domain. B7-H2 costimulation via CD28 induced survival factor Bcl-xL, downregulated cell cycle inhibitor p27^kip1 and triggered signaling cascade of ERK and AKT kinases-dependent pathways^[1][2]. B7-H2/ICOSLG Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived B7-H2/ICOSLG protein, expressed by HEK293 , with C-hFc labeled tag.

B7-H2 interacted with CD28 in a non-overlapping domain as B7-1 and B7-2, and was essential for the costimulation of human T cells’ primary responses to allogeneic antigens and memory recall responses. B7-H2 is a costimulatory ligand for CD28. The non-competing nature of B7-H2 and B7-1or B7-2 for binding CD28 suggests these ligands could work independently, simultaneously, and even synergistically to provide maximal CD28 costimulation for T cells^[1].

Cynomolgus

HEK293

C-hFc

XP_005548618 (M1-T256)

102132485  [NCBI]

Partial

Approximately 53.3 kDa.

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.