APJ Protein-VLP, Human (HEK293)

APJ Protein-VLP, Human (HEK293) is the recombinant human-derived APJ protein, expressed by HEK293, with tag free tag.

APJ is a G protein-coupled receptor that binds peptide hormones apelin (APLN) and apelin receptor early endogenous ligand (APELA/ELA), playing a central role in regulating normal cardiovascular function and fluid homeostasis. As an apelin receptor, it activates both the G(i) protein pathway (inhibiting adenylate cyclase activity) and the beta-arrestin pathway (promoting receptor internalization). APLNR/APJ also functions as a mechanoreceptor, activated by pathological stimuli in a G-protein-independent manner to induce beta-arrestin signaling, thereby triggering cardiac hypertrophy, though apelin ligand presence blunts this pathological induction. During early development, it acts as an APELA receptor in gastrulation, blood vessel formation, and heart morphogenesis (by similar). It may promote angioblast migration toward the embryonic midline (future vessel formation site) (by similar) and drive sinus venosus (SV)-derived endothelial cell migration into the developing heart to support coronary vessel development (by similar). In adults, it further regulates blood vessel formation, blood pressure, heart contractility, and heart failure.

Human

HEK293

Tag Free

P35414 (M1-D380)

187

Full Length

Greater than 95% as determined by HPLC.

<1 EU/μg, determined by LAL method.