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  5. Acetylcholinesterase/ACHE Protein, Human (Active, HEK293, His)

Acetylcholinesterase/ACHE Protein, Human (Active, HEK293, His)

Cat. No.: HY-P704343
Handling Instructions Technical Support

Acetylcholinesterase (ACHE) protein is pivotal in neurotransmission, rapidly hydrolyzing acetylcholine in the synaptic cleft to terminate signal transduction at the neuromuscular junction. Beyond neurotransmitter regulation, ACHE is implicated in neuronal apoptosis, indicating a broader role in cellular processes associated with programmed cell death. Acetylcholinesterase/ACHE Protein, Human (Active, HEK293, His) is the recombinant human-derived Acetylcholinesterase/ACHE protein, expressed by HEK293, with C-His labeled tag.

For research use only. We do not sell to patients.

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Description

Acetylcholinesterase (ACHE) protein is pivotal in neurotransmission, rapidly hydrolyzing acetylcholine in the synaptic cleft to terminate signal transduction at the neuromuscular junction. Beyond neurotransmitter regulation, ACHE is implicated in neuronal apoptosis, indicating a broader role in cellular processes associated with programmed cell death. Acetylcholinesterase/ACHE Protein, Human (Active, HEK293, His) is the recombinant human-derived Acetylcholinesterase/ACHE protein, expressed by HEK293, with C-His labeled tag.
Background

Acetylcholinesterase (ACHE) protein plays a crucial role in neurotransmission by rapidly hydrolyzing the acetylcholine neurotransmitter in the synaptic cleft, thereby facilitating the termination of signal transduction at the neuromuscular junction. Beyond its essential function in neurotransmitter regulation, ACHE is implicated in neuronal apoptosis, suggesting a broader role in cellular processes related to programmed cell death.
Species

Human
Source

HEK293
Tag

C-His
Accession

P22303-1 (E32-L614)
Gene ID

43
Molecular Construction
N-term
ACHE (E32-L614)
Accession # P22303
His
C-term
Protein Length

Full Length of Isoform-1 Mature Protein
Synonyms
acetylcholinesterase (Yt blood group); Acetylcholinesterase; ACHE; apoptosis-related acetylcholinesterase; ARACHE; EC 3.1.1; EC 3.1.1.7; N-ACHE; Yt blood group; YT
Predicted Molecular Mass
66.5 kDa
Molecular Weight

Approximately 65-80 kDa,based on SDS-PAGE under reducing conditions,due to the glycosylation.
Glycosylation
Yes
Purity

Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

Acetylcholinesterase/ACHE Protein, Human (Active, HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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