2. Recombinant Proteins
  3. Enzymes & Regulators
  4. Translocases (EC 7)
  5. ABCB11 Protein, Human (sf9, Flag, His)

ABCB11 Protein, Human (sf9, Flag, His) is the recombinant human-derived ABCB11, expressed by sf9 insect cells, with His, Flag labeled tag.

For research use only. We do not sell to patients.

Surface Plasmon Resonance (SPR) Assay Service   Protein Expression Service

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Description

ABCB11 Protein, Human (sf9, Flag, His) is the recombinant human-derived ABCB11, expressed by sf9 insect cells, with His, Flag labeled tag.
Background

ABCB11 is an ATP-dependent transporter that primarily facilitates the transport of major hydrophobic bile salts, such as tauro- and glyco-conjugated cholic acid, across the canalicular membrane of hepatocytes. It plays a crucial role in hepatic bile acid homeostasis and indirectly regulates lipid homeostasis by controlling biliary lipid secretion in a bile salt-dependent manner. This transporter exhibits a higher transport rate for tauro-conjugated bile salts compared to glyco-conjugated ones. Additionally, ABCB11 mediates the ATP-dependent transport of non-bile acid compounds like pravastatin and fexofenadine, potentially contributing to their biliary excretion. by similar
Species

Human
Source

Sf9 insect cells
Tag

His;Flag
Accession

O95342 (M1-S1321)
Gene ID

8647
Protein Length

Full Length
Synonyms
BSEP
Predicted Molecular Mass
149.8 kDa
Glycosylation
Yes
Purity

Greater than 80% as determined by reducing SDS-PAGE
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

ABCB11 Protein, Human (sf9, Flag, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Reconstitution Calculator

  • Dilution Calculator

  • Specific Activity Calculator

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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