2. Antibody-drug Conjugate/ADC Related Immunology/Inflammation
  3. ADC Antibody Transmembrane Glycoprotein
  4. Raludotatug

Raludotatug is a humanized anti-CDH6 IgG1 monoclonal antibody. Raludotatug has antitumor activity and can be used to synthesize the ADC molecule Raludotatug deruxtecan (HY-164734).

For research use only. We do not sell to patients.

CAS No. : 2610074-56-9

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Based on 1 publication(s) in Google Scholar

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Description

Raludotatug is a humanized anti-CDH6 IgG1 monoclonal antibody. Raludotatug has antitumor activity and can be used to synthesize the ADC molecule Raludotatug deruxtecan (HY-164734)[1].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
IC50 & Target

CDH6
In Vitro

The ADC molecule Raludotatug deruxtecan (HY-164734) is composed of the humanized anti-CDH6 IgG1 monoclonal antibody Raludotatug, a cleavable GGFG tetrapeptide linker, and the topoisomerase I inhibitor DXd (HY-13631D). Raludotatug deruxtecan can be used for research on tumors such as ovarian cancer and renal cancer[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Raludotatug Related Antibodies
Clinical Trial
Gene ID

102144314  [NCBI]

Accession

G7MUQ7 / XP_005556691
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

145.702 kDa

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Raludotatug]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Biological Activity
  • Immobilized Human CDH6/K-Cadherin, His Tag can bind Raludotatug. The EC50 for this effect is 11.54 ng/mL.
Purity & Documentation

Purity: 99.00%

SDS (251 KB)

COA (232 KB) SDS-PAGE (99 KB) SEC-HPLC (523 KB)

Inhibitory Antibodies User Guide (602 KB)
References
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Raludotatug Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Raludotatug2610074-56-9ADC AntibodyTransmembrane GlycoproteinG1-kappaCDH6antineoplasticcancerInhibitorinhibitorinhibit

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Raludotatug
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HY-P990028
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