2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. EGF Superfamily
  5. Neuregulins

Neuregulins

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Neuregulins, a family of EGF-like signaling molecules, are paracrine, autocrine, and juxtacrine signaling peptides which mediate a myriad of cellular functions including survival, proliferation, and differentiation in both neuronal and non-neural systems. Neuregulins are involved in cell-cell crosstalk and play an important role in development, maintenance and repair of the nervous system, heart, breast and other organs. The neuregulin family of ligands has four members: NRG1, NRG2, NRG3, and NRG4. Neuregulins transmit their signals to target cells by interacting with transmembrane tyrosine kinase receptors of the ErbB (HER) family. Receptor-ligand interaction induces the heterodimerization of receptor monomers, which in turn results in the activation of intracellular signaling cascades and the induction of cellular responses.

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Cat. No. Product Name / Synonyms Species Source
  • HY-P73328
    NRG1-beta 1 Protein, Human (HEK293)

    Pro-neuregulin-1; Neuregulin-1; ARIA; HRG; NRG1; GGF; HGL; HRGA; NDF; SMDF

    		Human HEK293
    NRG1-beta 1 Protein, Human (HEK293) is the recombinant human-derived NRG1-beta 1 protein, expressed by HEK293 , with tag free.
  • HY-P73326
    NRG1-alpha Protein, Human (HEK293, His)

    Pro-neuregulin-1; Neuregulin-1; ARIA; HRG; NRG1; GGF; HGL; HRGA; NDF; SMDF

    		Human HEK293
    NRG1-α protein binds directly to ERBB3 and ERBB4 receptors, leading to the recruitment of ERBB1 and ERBB2 coreceptors. NRG1-alpha Protein, Human (HEK293, His) is the recombinant human-derived NRG1-alpha protein, expressed by HEK293 , with C-His, C-6*His labeled tag.
  • HY-P73329
    NRG1-beta 1 Protein, Human (245a.a, HEK293, Fc)

    Pro-neuregulin-1; Neuregulin-1; ARIA; HRG; NRG1; GGF; HGL; HRGA; NDF; SMDF

    		Human HEK293
    HRG1-β1 belongs to a family of structurally-related polypeptide growth factors derived from alternatively spliced genes, induces Fn14 expression in MCF7 cells. NRG1-beta 1 Protein, Human (245a.a, HEK293, Fc) is the recombinant human-derived NRG1-beta 1 protein, expressed by HEK293 , with N-hFc labeled tag.
  • HY-P702533
    Neuregulin-1/NRG1 Protein, Mouse (HEK293, His)

    ARIA; GGF2; GGFglial growth factor; Heregulin-1; HGL; HGLneu differentiation factor; HRG; HRG1; HRG1-alpha; HRG1-beta 1; HRGAneuregulin 1 type IV beta 1a; MST131; MSTP131; NDFheregulin, alpha (45kD, ERBB2 p185-activator); neuregulin 1 type IV beta 3; neuregulin 1; Neuregulin1; Neuregulin-1; NRG1; pro-neuregulin-1, membrane-bound isoform; pro-NRG1; sensory and motor neuron derived factor; SMDF

    		Mouse HEK293
    NRG1 Protein is a direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells. Binds to ERBB4 and ERBB3. Neuregulin-1/NRG1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Neuregulin-1/NRG1 protein, expressed by HEK293 , with C-6*His labeled tag.
  • HY-P72007
    NRG1-beta 1 Protein, Human (65a.a, His)

    Pro-neuregulin-1; Neuregulin-1 beta 1; NRG1-beta 1; HRG1-beta 1; EGF; NRG1; GGF; HGL; HRGA; NDF; SMDF; Heregulin β-1; Heregulin; HRG

    		Human E. coli
    HRG1-β1 belongs to a family of structurally-related polypeptide growth factors derived from alternatively spliced genes, induces Fn14 expression in MCF7 cells. NRG1-beta 1 Protein, Human (65a.a, His) is the recombinant human-derived NRG1-beta 1 protein, expressed by E. coli , with N-6*His labeled tag.
  • HY-P7365
    NRG1-beta 1 Protein, Human

    rHuHeregulin-1 β1; ARIA; HRG; NRG1; Neuregulin-1

    		Human E. coli
    HRG1-β1 belongs to a family of structurally-related polypeptide growth factors derived from alternatively spliced genes, induces Fn14 expression in MCF7 cells. NRG-1 Protein, Human is the recombinant human-derived HRG1-β1, expressed by E. coli , with tag Free labeled tag.
  • HY-P73304
    NRG1-beta 2 Protein, Human

    NRG-1 EGF-like domain beta 2; Beta2; Neuregulin-1 beta 2

    		Human E. coli
    HRG1-β1 belongs to a family of structurally-related polypeptide growth factors derived from alternatively spliced genes, induces Fn14 expression in MCF7 cells. NRG1-beta 2 Protein, Human is the recombinant human-derived NRG1-beta 2 protein, expressed by E. coli , with tag free.
  • HY-P74709
    Neuregulin-1/NRG1 Protein, Canine (HEK293)

    Pro-NRG1; Neuregulin-1; ARIA; HRG; NRG1

    		Canine HEK293
    Neuregulin-1/NRG1 Protein, Canine (HEK293) is the recombinant canine-derived Neuregulin-1/NRG1 protein, expressed by HEK293 , with tag free.
  • HY-P74682
    Neuregulin-2/NRG2 Protein, Human (HEK293, His)

    Pro-neuregulin-2; Pro-NRG2; Neuregulin-2; DON-1; NTAK; NRG-2

    		Human HEK293
    Neuregulin-2/NRG2 protein serves as a direct ligand for the ERBB3 and ERBB4 tyrosine kinase receptors, initiating ligand-stimulated tyrosine phosphorylation and activation of these receptors. At the same time, NRG2 simultaneously recruits ERBB1 and ERBB2 coreceptors, possibly promoting heterodimerization with the EGF receptor. Neuregulin-2/NRG2 Protein, Human (HEK293, His) is the recombinant human-derived Neuregulin-2/NRG2 protein, expressed by HEK293 , with C-His labeled tag.
  • HY-P75944
    Neuregulin-3/NRG3 Protein, Human (61a.a, HEK293, His)

    Pro-NRG3; Neuregulin-3; NRG-3; NRG3

    		Human HEK293
    Neuregulin-3/NRG3 proteins are important members of the neuregulin family that influence cell signaling and development and contribute to a variety of biological processes. Their unique structural features, lacking conserved residues critical for feature annotation propagation, suggest different regulatory mechanisms or interactions. Neuregulin-3/NRG3 Protein, Human (61a.a, HEK293, His) is the recombinant human-derived Neuregulin-3/NRG3 protein, expressed by HEK293 , with C-His labeled tag.
  • HY-P76524
    Neuregulin-4/NRG4 Protein, Human

    Pro-neuregulin-4, membrane-bound isoform; Pro-NRG4; NRG-4

    		Human E. coli
    Neuregulin-4 (NRG4) Protein, a low-affinity ligand for the ERBB4 tyrosine kinase receptor, serves as a signaling molecule that recruits ERBB1 and ERBB2 coreceptors. This recruitment leads to ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. NRG4 specifically interacts with the ERBB4 receptor, mediating cellular responses through its activation, without binding to ERBB1, ERBB2, and ERBB3 receptors. Neuregulin-4/NRG4 Protein, Human is the recombinant human-derived Neuregulin-4/NRG4 protein, expressed by E. coli , with tag free.
  • HY-P70967
    NRG1-beta 1 Protein, Human (246a.a, His)

    Pro-neuregulin-1; Neuregulin-1 beta 1; NRG1-beta 1; HRG1-beta 1 ECD; NRG1; GGF; HGL; HRGA; NDF; SMDF;

    		Human E. coli
    NRG1 is a direct ligand of the ERBB3 and ERBB4 tyrosine kinase receptors. NRG1 can induce the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2 and AKT1. NRG1 can induce cell growth, differentiation and proliferation. NRG1-beta 1 Protein, Human (246a.a, His) is the recombinant human-derived NRG1-beta 1 protein, expressed by E. coli , with N-6*His labeled tag.
  • HY-P71171A
    NRG1-beta 1 Protein, Human (CHO)

    Pro-neuregulin-1; Neuregulin-1 beta 1; NRG1-beta 1; HRG1-beta 1; EGF; NRG1; GGF; HGL; HRGA; NDF; SMDF; Heregulin β-1; Heregulin; HRG

    		Human CHO
    HRG1-β1 belongs to a family of structurally-related polypeptide growth factors derived from alternatively spliced genes, induces Fn14 expression in MCF7 cells. NRG1-beta 1 Protein, Human (CHO) is the recombinant human-derived NRG1-beta 1 protein, expressed by CHO , with tag free.
  • HY-P70524
    NRG1-beta 1 Protein, Human (245a.a)

    Pro-neuregulin-1; Neuregulin-1 beta 1; NRG1-beta 1; HRG1-beta 1; EGF; NRG1; GGF; HGL; HRGA; NDF; SMDF;

    		Human E. coli
    HRG1-β1 belongs to a family of structurally-related polypeptide growth factors derived from alternatively spliced genes, induces Fn14 expression in MCF7 cells. NRG1-beta 1 Protein, Human (245a.a) is the recombinant human-derived NRG1-beta 1 protein, expressed by E. coli , with tag free.
  • HY-P73327
    NRG1-alpha Protein, Human (65a.a, HEK293, Fc)

    Pro-neuregulin-1; Neuregulin-1; ARIA; HRG; NRG1; GGF; HGL; HRGA; NDF; SMDF

    		Human HEK293
    NRG1-α protein binds directly to ERBB3 and ERBB4 receptors, leading to the recruitment of ERBB1 and ERBB2 coreceptors. NRG1-alpha Protein, Human (65a.a, HEK293, Fc) is the recombinant human-derived NRG1-alpha protein, expressed by HEK293 , with N-hFc labeled tag.
  • HY-P700427
    NRG1-beta 1 Protein, Human (HEK293, His)

    Pro-neuregulin-1; Neuregulin-1 beta 1; NRG1-beta 1; HRG1-beta 1; EGF; NRG1; GGF; HGL; HRGA; NDF; SMDF; Heregulin β-1; Heregulin; HRG

    		Human HEK293
    HRG1-β1 belongs to a family of structurally-related polypeptide growth factors derived from alternatively spliced genes, induces Fn14 expression in MCF7 cells. NRG1-beta 1 Protein, Human (HEK293, His) is the recombinant human-derived NRG1-beta 1 protein, expressed by HEK293 , with C-6*His labeled tag.
  • HY-P73330
    NRG1-beta 1 Protein, Human (71a.a, HEK293, Fc)

    Pro-neuregulin-1; Neuregulin-1; ARIA; HRG; NRG1; GGF; HGL; HRGA; NDF; SMDF

    		Human HEK293
    HRG1-β1 belongs to a family of structurally-related polypeptide growth factors derived from alternatively spliced genes, induces Fn14 expression in MCF7 cells. NRG1-beta 1 Protein, Human (71a.a, HEK293, Fc) is the recombinant human-derived NRG1-beta 1 protein, expressed by HEK293 , with N-hFc labeled tag.
  • HY-P74710
    Neuregulin-1/NRG1 Protein, Canine (65a.a, HEK293, mFc)

    Pro-NRG1; Neuregulin-1; ARIA; HRG; NRG1

    		Canine HEK293
    Neuregulin-1/NRG1 Protein, Canine (65a.a, HEK293, mFc) is the recombinant canine-derived Neuregulin-1/NRG1 protein, expressed by HEK293 , with N-mFc labeled tag.
  • HY-P74712
    Neuregulin-1/NRG1 Protein, Canine (222a.a, HEK293, His)

    Pro-NRG1; Neuregulin-1; ARIA; HRG; NRG1

    		Canine HEK293
    Neuregulin-1/NRG1 Protein, Canine (222a.a, HEK293, His) is the recombinant canine-derived Neuregulin-1/NRG1 protein, expressed by HEK293 , with C-His labeled tag.
  • HY-P74713
    Neuregulin-1/NRG1 Protein, Canine (222a.a, HEK293, hFc)

    Pro-NRG1; Neuregulin-1; ARIA; HRG; NRG1

    		Canine HEK293
    Neuregulin-1/NRG1 Protein, Canine (222a.a, HEK293, hFc) is the recombinant canine-derived Neuregulin-1/NRG1 protein, expressed by HEK293 , with C-hFc labeled tag.
Cat. No. Product Name Effect Purity