2. Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. PPAR
  4. PPAR agonist 5

PPAR agonist 5 (compound 4b) is a potent PPAR agonist with EC50 values of 3.20, 1.51, 1.92 µM for PPARα, PPARβ/δ, PPARγ, respectively. PPAR agonist 5 shows anti-inflammatory effect.

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PPAR agonist 5

PPAR agonist 5 Chemical Structure

CAS No. : 3059387-62-8

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Based on 1 publication(s) in Google Scholar

PPAR agonist 5 Related Antibodies

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Description

PPAR agonist 5 (compound 4b) is a potent PPAR agonist with EC50 values of 3.20, 1.51, 1.92 µM for PPARα, PPARβ/δ, PPARγ, respectively. PPAR agonist 5 shows anti-inflammatory effect[1].

IC50 & Target[1]

PPARα

3.20 μM (EC50)

PPARβ/δ

1.51 μM (EC50)

PPARγ

1.92 μM (EC50)

In Vitro

PPAR agonist 5 (compound 4b) (10 µM; 4, 24 h) decrease LPS (HY-D1056) induced mRNA expression of CCL-2 and IL-6[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PPAR agonist 5 Related Antibodies

RT-PCR[1]

Cell Line: THP-1 human monocytes differentiated into macrophages
Concentration: 10 µM
Incubation Time: 4, 24 h
Result: Decreased the LPS (HY-D1056) (10 ng/mL)-induced expression of CCL-2 at 4 and 24 h and the expression of IL-6 at 24 h.
Molecular Weight

403.51

Formula

C26H29NO3
CAS No.
Appearance

Liquid

Color

Light yellow to brown

SMILES

O=C(OCC)CC/C(C)=C/CCC1=NC2=CC=C(OCC3=CC=CC=C3)C=C2C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (123.91 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4783 mL 12.3913 mL 24.7825 mL
5 mM 0.4957 mL 2.4783 mL 4.9565 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4783 mL 12.3913 mL 24.7825 mL 61.9563 mL
5 mM 0.4957 mL 2.4783 mL 4.9565 mL 12.3913 mL
10 mM 0.2478 mL 1.2391 mL 2.4783 mL 6.1956 mL
15 mM 0.1652 mL 0.8261 mL 1.6522 mL 4.1304 mL
20 mM 0.1239 mL 0.6196 mL 1.2391 mL 3.0978 mL
25 mM 0.0991 mL 0.4957 mL 0.9913 mL 2.4783 mL
30 mM 0.0826 mL 0.4130 mL 0.8261 mL 2.0652 mL
40 mM 0.0620 mL 0.3098 mL 0.6196 mL 1.5489 mL
50 mM 0.0496 mL 0.2478 mL 0.4957 mL 1.2391 mL
60 mM 0.0413 mL 0.2065 mL 0.4130 mL 1.0326 mL
80 mM 0.0310 mL 0.1549 mL 0.3098 mL 0.7745 mL
100 mM 0.0248 mL 0.1239 mL 0.2478 mL 0.6196 mL
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PPAR agonist 5 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PPAR agonist 53059387-62-8PPAR agonist5PPAR agonist-5PPARPeroxisome proliferator-activated receptorsmacrophagesCCL-2IL-6anti-inflammatoryInhibitorinhibitorinhibit

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