2. PI3K/Akt/mTOR Apoptosis
  3. PI3K Akt Apoptosis
  4. PI3Kδ-IN-24

PI3Kδ-IN-24 is a selective PI3Kδ inhibitor (IC50 = 0.1 nM). PI3Kδ-IN-24 exhibits significant antiproliferative effects against PI3Kδ-overexpressing cancer cell lines. PI3Kδ-IN-24 reduces p-AKT levels and induces cell cycle arrest and apoptosis in tumor cells. PI3Kδ-IN-24 is useful in cancer research, such as diffuse large B-cell lymphoma (DLBCL).

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PI3Kδ-IN-24

PI3Kδ-IN-24 Chemical Structure

CAS No. : 3051829-20-7

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PI3Kδ-IN-24 Related Antibodies

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Description

PI3Kδ-IN-24 is a selective PI3Kδ inhibitor (IC50 = 0.1 nM). PI3Kδ-IN-24 exhibits significant antiproliferative effects against PI3Kδ-overexpressing cancer cell lines. PI3Kδ-IN-24 reduces p-AKT levels and induces cell cycle arrest and apoptosis in tumor cells. PI3Kδ-IN-24 is useful in cancer research, such as diffuse large B-cell lymphoma (DLBCL)[1].

IC50 & Target[1]

PI3Kδ

0.1 nM (IC50)

PI3Kγ

1.97 nM (IC50)

PI3Kα

97.85 nM (IC50)

In Vitro

PI3Kδ-IN-24 (Compound M7) (72 h) inhibits cell growth against SU-DHL-6 and Pfeiffer cells, with GI50s of 0.012 μM and 0.068 μM, and exhibits weak antiproliferative activity against HCT-116, MCF-7 and Raji cells, with GI50s of 1.20 μM, 2.56 μM, 6.83 μM[1].
PI3Kδ-IN-24 (10-1000 nM, 24 h) continuously inhibits AKT phosphorylation in SU-DHL-6 cells[1].
PI3Kδ-IN-24 (10 μM, 0.5 h) increases the thermal stability of endogenous PI3Kδ in SU-DHL-6 cells[1].
PI3Kδ-IN-24 (0.01-1 μM, 24-72 h) arrests the growth in the G0/G1 phase and triggers apoptosis in SU-DHL-6 cells, but does not induce apoptosis in HEK293 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PI3Kδ-IN-24 Related Antibodies

Western Blot Analysis[1]

Cell Line: SU-DHL-6 cells
Concentration: 10 nM, 33 nM, 100 nM, 333 nM, 1000 nM
Incubation Time: 24 h
Result: Reduced the expression level of p-AKT.

Cell Cycle Analysis[1]

Cell Line: SU-DHL-6 cells
Concentration: 0.01 μM, 0.1 μM, 1 μM
Incubation Time: 24 h
Result: Arrested the growth in the G0/G1 phase, blocked over 50 % in this phase at 0.1 μM, surpassing the efficacy of Idelalisib (HY-13026) at 10 μM.

Apoptosis Analysis[1]

Cell Line: SU-DHL-6 cells
Concentration: 0.01 μM, 0.1 μM, 1 μM
Incubation Time: 72 h
Result: Triggered apoptosis, induced apoptosis in approximately 60 % at 1 μM, surpassed Idelalisib in its capacity to promote apoptosis.
Molecular Weight

527.57

Formula

C28H29N7O4
CAS No.
SMILES

COC1=C(C=C(C2=CC=C3N=CN=C(C3=N2)N[C@@H](C)C(N4CCN(CC4)C)=O)C=N1)C(OC5=CC=CC=C5)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PI3Kδ-IN-24 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PI3Kδ-IN-243051829-20-7PI3KAktApoptosisPhosphoinositide 3-kinasePKBProtein kinase BInhibitorSU-DHL-6 cellsPfeiffer cellsinhibitorinhibit

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