2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation
  3. Histamine Receptor
  4. N-Methylhistamine dihydrochloride

N-Methylhistamine dihydrochloride  (Synonyms: Nα-Methylhistamine dihydrochloride)

Cat. No.: HY-101005 Purity: 99.20%
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N-Methylhistamine (Nα-Methylhistamine) dihydrochloride is a potent agonist of the histamine H3 receptor, exhibiting significant implications in the diagnosis and management of mastocytosis. N-Methylhistamine (dihydrochloride) also serves as a biomarker for assessing mast cell accumulation in clinical evaluations.

For research use only. We do not sell to patients.

N-Methylhistamine dihydrochloride

N-Methylhistamine dihydrochloride Chemical Structure

CAS No. : 16503-22-3

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Based on 1 publication(s) in Google Scholar

N-Methylhistamine dihydrochloride Related Antibodies

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Description

N-Methylhistamine (Nα-Methylhistamine) dihydrochloride is a potent agonist of the histamine H3 receptor, exhibiting significant implications in the diagnosis and management of mastocytosis. N-Methylhistamine (dihydrochloride) also serves as a biomarker for assessing mast cell accumulation in clinical evaluations.

Molecular Weight

198.09

Formula

C6H13Cl2N3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CNCCC1=CN=CN1.Cl.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 4.17 mg/mL (21.05 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.0482 mL 25.2411 mL 50.4821 mL
5 mM 1.0096 mL 5.0482 mL 10.0964 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 5.0482 mL 25.2411 mL 50.4821 mL 126.2053 mL
5 mM 1.0096 mL 5.0482 mL 10.0964 mL 25.2411 mL
10 mM 0.5048 mL 2.5241 mL 5.0482 mL 12.6205 mL
15 mM 0.3365 mL 1.6827 mL 3.3655 mL 8.4137 mL
20 mM 0.2524 mL 1.2621 mL 2.5241 mL 6.3103 mL
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N-Methylhistamine dihydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N-Methylhistamine16503-22-3Nα-MethylhistamineHistamine ReceptorInhibitorinhibitorinhibit

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