2. Immunology/Inflammation
  3. NOD-like Receptor (NLR)
  4. MS-II-124

MS-II-124 is an effective and selective NLRP3 inhibitor (IC50=0.12 μM) with anti-inflammatory and immunomodulatory activities, which can be used in the research of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS).

For research use only. We do not sell to patients.

MS-II-124

MS-II-124 Chemical Structure

CAS No. : 3037332-85-4

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO In-stock
Solid
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10 mg In-stock
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Based on 1 publication(s) in Google Scholar

MS-II-124 Related Antibodies

Top Publications Citing Use of Products

View All NOD-like Receptor (NLR) Isoform Specific Products:

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NLRP3 NLRP1 NOD1 NOD2

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

MS-II-124 is an effective and selective NLRP3 inhibitor (IC50=0.12 μM) with anti-inflammatory and immunomodulatory activities, which can be used in the research of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS)[1].

IC50 & Target

IC50=0.12 μM (NLRP3)[1].
In Vivo

MS-II-124 (10 mg/kg; i.p.; single dose) reduces lung inflammation and immune cell infiltration in the LPS (HY-D1056) ( i.n. instillation, 40 μg in 40 μL PBS) -induced ALI/ARDS wild-type mouse model, exhibiting anti-inflammatory and immunomodulatory activities[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ALI/ARDS WT C57BL/6 mice model[1].
Dosage: 10 mg/kg
Administration: Intraperitoneal injection (i.p.), Single dose. 1 h before i.n. instillation of LPS (40 μg in 40 μL PBS).
Result: Significantly inhibited lipopolysaccharide (LPS)-induced IL-1β production in pulmonary bronchoalveolar lavage fluid (BALF), whereas NLRP3 deletion did not significantly inhibit its production.
Molecular Weight

543.05

Formula

C28H28ClFN2O4S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

ClC1=CC=C(OCCC)C(CN(CCC2=CC=C(S(=O)(NCC#C)=O)C=C2)C(C3=CC=C(F)C=C3)=O)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 35 mg/mL (64.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8415 mL 9.2073 mL 18.4145 mL
5 mM 0.3683 mL 1.8415 mL 3.6829 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8415 mL 9.2073 mL 18.4145 mL 46.0363 mL
5 mM 0.3683 mL 1.8415 mL 3.6829 mL 9.2073 mL
10 mM 0.1841 mL 0.9207 mL 1.8415 mL 4.6036 mL
15 mM 0.1228 mL 0.6138 mL 1.2276 mL 3.0691 mL
20 mM 0.0921 mL 0.4604 mL 0.9207 mL 2.3018 mL
25 mM 0.0737 mL 0.3683 mL 0.7366 mL 1.8415 mL
30 mM 0.0614 mL 0.3069 mL 0.6138 mL 1.5345 mL
40 mM 0.0460 mL 0.2302 mL 0.4604 mL 1.1509 mL
50 mM 0.0368 mL 0.1841 mL 0.3683 mL 0.9207 mL
60 mM 0.0307 mL 0.1535 mL 0.3069 mL 0.7673 mL
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MS-II-124 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MS-II-1243037332-85-4NOD-like Receptor (NLR)acute lung injury (ALI)acute respiratory distress syndrome (ARDS)WT C57BL/6 miceInhibitorinhibitorinhibit

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