2. NF-κB
  3. NF-κB
  4. MnTBAP chloride

MnTBAP chloride is a superoxide dismutase (SOD) mimetic and peroxynitrite scavenger. MnTBAP chloride is a manganic porphyrin complex and has anti-oxidative property. MnTBAP chloride mediates anti-inflammatory effects through upregulation of BMPR-II and inhibition of the NFκB signaling. MnTBAP chloride has the potential for the fibrotic response in chronic kidney diseases (CKDs) research.

For research use only. We do not sell to patients.

MnTBAP chloride Chemical Structure

MnTBAP chloride Chemical Structure

CAS No. : 55266-18-7

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Based on 3 publication(s) in Google Scholar

MnTBAP chloride Related Antibodies

Top Publications Citing Use of Products

    MnTBAP chloride purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2022 Nov 17;S0891-5849(22)00992-3.  [Abstract]

    The decreased protein expression levels of the ferroptosis repressors NRF2, SLC7A11, and GPX4 after cisplatin stimuli are rescued by 84-B10 (40 µM), MnTBAP (80 µM), and Lipro-1 (2 µM) pretreat for 2 h, in TKPT cells.

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    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    MnTBAP chloride is a superoxide dismutase (SOD) mimetic and peroxynitrite scavenger. MnTBAP chloride is a manganic porphyrin complex and has anti-oxidative property. MnTBAP chloride mediates anti-inflammatory effects through upregulation of BMPR-II and inhibition of the NFκB signaling. MnTBAP chloride has the potential for the fibrotic response in chronic kidney diseases (CKDs) research[1][2].

    IC50 & Target[1][2]

    NFκB

     

    In Vitro

    MnTBAP chloride (pretreated 1.14 μM before TGF-β1 of 10 ng/mL) partially but significantly restores E-cadherin reduction and suppresses the induction of α-SMA and vimentin in immortalized mouse proximal tubular cells (mPTCs)[1].
    MnTBAP chloride (50 μM; 6 hours) increases BMPR-II mRNA by 1.3-fold at 2 h, but does not affect protein expression of BMPR-II during a time course of 16 h in HUVECs. MnTBAP chloride increases phosphorylation of Smad 1/5, suggesting modulation of the BMP signaling pathway[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    MnTBAP chloride Related Antibodies
    In Vivo

    MnTBAP chloride (10 mg/kg; IP; three times per week for twelve weeks) attenuates renal fibrosis in 5/6 Nx mice[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: C57BL/6J mice with 5/6 nephrectomy (Nx)[1]
    Dosage: 10 mg/kg
    Administration: IP; three times per week for twelve weeks
    Result: Attenuated renal fibrosis in 5/6 Nx mice and reduced protein expressions of fibronectin, collagen III in remnant kidneys.
    Molecular Weight

    879.15

    Formula

    C48H28ClMnN4O8
    CAS No.
    Appearance

    Solid

    Color

    Brown to black

    SMILES

    [Cl-][Mn+3]12([N](C(C=C3)=C4C(C=C5)=CC=C5C(O)=O)=C3C(C(C=C6)=CC=C6C(O)=O)=C7C=C8)[N-]7C8=C(C(C=C9)=CC=C9C(O)=O)C%10=[N]1C(C=C%10)=C(C(C=C%11)=CC=C%11C(O)=O)C%12=CC=C4[N-]2%12
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    -20°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    1 M NaOH : 100 mg/mL (113.75 mM; Need ultrasonic)

    0.5 M NaOH : 20 mg/mL (22.75 mM; Need ultrasonic and warming)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.1375 mL 5.6873 mL 11.3746 mL
    5 mM 0.2275 mL 1.1375 mL 2.2749 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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    Working solution concentration: mg/mL
    Purity & Documentation

    Purity: ≥98.0%

    SDS (393 KB)

    COA (262 KB) HNMR (359 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    0.5 M NaOH / 1 M NaOH 1 mM 1.1375 mL 5.6873 mL 11.3746 mL 28.4366 mL
    5 mM 0.2275 mL 1.1375 mL 2.2749 mL 5.6873 mL
    10 mM 0.1137 mL 0.5687 mL 1.1375 mL 2.8437 mL
    15 mM 0.0758 mL 0.3792 mL 0.7583 mL 1.8958 mL
    20 mM 0.0569 mL 0.2844 mL 0.5687 mL 1.4218 mL
    1 M NaOH 25 mM 0.0455 mL 0.2275 mL 0.4550 mL 1.1375 mL
    30 mM 0.0379 mL 0.1896 mL 0.3792 mL 0.9479 mL
    40 mM 0.0284 mL 0.1422 mL 0.2844 mL 0.7109 mL
    50 mM 0.0227 mL 0.1137 mL 0.2275 mL 0.5687 mL
    60 mM 0.0190 mL 0.0948 mL 0.1896 mL 0.4739 mL
    80 mM 0.0142 mL 0.0711 mL 0.1422 mL 0.3555 mL
    100 mM 0.0114 mL 0.0569 mL 0.1137 mL 0.2844 mL
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    MnTBAP chloride Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    MnTBAP55266-18-7NF-κBNuclear factor-κBNuclear factor-kappaBsuperoxidedismutaseSODscavengeranti-oxidativeBMPR-IINFκBfibroticresponsechronickidneyCKDsInhibitorinhibitorinhibit

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