2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. MK-212 monohydrochloride

MK-212 monohydrochloride  (Synonyms: CPP monohydrochloride)

Cat. No.: HY-101324A Purity: 99.62%
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MK-212 (CPP) monohydrochloride is a centrally acting 5-HT1C/5-HT2 agonist. MK-212 monohydrochloride can stimulate phosphoinositide hydrolysis in cerebral cortex.

For research use only. We do not sell to patients.

MK-212 monohydrochloride Chemical Structure

MK-212 monohydrochloride Chemical Structure

CAS No. : 61655-58-1

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Based on 1 publication(s) in Google Scholar

Other Forms of MK-212 monohydrochloride:

MK-212 monohydrochloride Related Antibodies

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Description

MK-212 (CPP) monohydrochloride is a centrally acting 5-HT1C/5-HT2 agonist. MK-212 monohydrochloride can stimulate phosphoinositide hydrolysis in cerebral cortex[1].

IC50 & Target[1]

5-HT1C Receptor

 

5-HT2 Receptor

 

Clinical Trial
Molecular Weight

235.12

Formula

C8H12Cl2N4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

ClC1=NC(N2CCNCC2)=CN=C1.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 10 mg/mL (42.53 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.2531 mL 21.2657 mL 42.5315 mL
5 mM 0.8506 mL 4.2531 mL 8.5063 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 4.2531 mL 21.2657 mL 42.5315 mL 106.3287 mL
5 mM 0.8506 mL 4.2531 mL 8.5063 mL 21.2657 mL
10 mM 0.4253 mL 2.1266 mL 4.2531 mL 10.6329 mL
15 mM 0.2835 mL 1.4177 mL 2.8354 mL 7.0886 mL
20 mM 0.2127 mL 1.0633 mL 2.1266 mL 5.3164 mL
25 mM 0.1701 mL 0.8506 mL 1.7013 mL 4.2531 mL
30 mM 0.1418 mL 0.7089 mL 1.4177 mL 3.5443 mL
40 mM 0.1063 mL 0.5316 mL 1.0633 mL 2.6582 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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MK-212 monohydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MK-212 monohydrochloride61655-58-1CPP monohydrochloride5-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorInhibitorinhibitorinhibit

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