2. Academic Validation
  3. Selenium Nanoplatform Engages Tranexamic Acid to Alleviate Ultraviolet B-Induced Skin Pigmentation via Inflammatory Response

Selenium Nanoplatform Engages Tranexamic Acid to Alleviate Ultraviolet B-Induced Skin Pigmentation via Inflammatory Response

  • ACS Nano. 2025 Jul 22;19(28):25744-25756. doi: 10.1021/acsnano.5c03980.
Jieqiong Cao 1 2,  Jingsheng Li 3 4,  Xiujuan Ren 3 4,  Yujie Xiao 3 4,  Yibo Zhang 3 4,  An Hong 1 3 4,  Dalong Ni 2 5,  Xiaojia Chen 1 3 4
Affiliations

Affiliations

  • 1 Department of Radiology, The First Affiliated Hospital of Jinan University, Guangzhou 510630, China.
  • 2 Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200001, China.
  • 3 State Key Laboratory of Bioactive Molecules and Druggability Assessment, Department of Cell Biology & Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou 510630, China.
  • 4 Guangdong Provincial Biotechnology Drug & Engineering Technology Research Center, National Engineering Research Center of Genetic Medicine, Guangzhou 510630, China.
  • 5 Department of Biomaterials and Stem Cells, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Science, Suzhou 215011, China.
PMID: 40637361 DOI: 10.1021/acsnano.5c03980
Abstract

Skin is the largest organ of the body and serves as a barrier against various environmental threats, including ultraviolet (UV) radiation, which could lead to pigmentation and an increased risk of melanoma. Oxidative stress has been identified as a significant factor in UV-induced skin pigmentation, yet there still remain significant challenges in understanding its role in vivo. Selenium nanoparticles have exhibited multiple bioactivities in many fields, but their application in skin diseases is limited. In this work, the zebrafish screen was first carried out in a transgene zebrafish larva cocultured with Nano-Se, which demonstrated a whitening effect of Nano-Se on pigmentation caused by UVB exposure in vivo. Further study showed that Nano-Se could also boost the effectiveness of tranexamic acid, combined with the whitening effect in relieving UVB-induced skin pigmentation and damage in mice. In a word, the Nano-Se described in this study offers an efficient and practical approach for synthesizing bioactive selenium nanoplatforms, broadening the application of nanoselenium to combat UVB-induced skin damage, and potentially revitalizing research of nanoselenium in various human diseases.

Keywords

inflammatory; nanoparticle; selenium nanoplatforms; skin damage; zebrafish.

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