2. Academic Validation
  3. Near-field electrospun 3D anisotropic fiber-hydrogel scaffold integrated with photothermal effect for skin wound healing

Near-field electrospun 3D anisotropic fiber-hydrogel scaffold integrated with photothermal effect for skin wound healing

  • Bioact Mater. 2025 Jun 7:52:200-212. doi: 10.1016/j.bioactmat.2025.05.034.
Ruinan Hao 1 2 3,  Hongtao Hu 2,  Xilin Ye 2,  Xiaofeng Chen 1,  Jinzhi Du 3,  Shuolei Li 4,  Chenglin Song 1,  Feng Tian 2,  Nana Zhao 2,  Fujian Xu 2,  Tao Zhang 5,  Feng Rao 1,  Jiajia Xue 2
Affiliations

Affiliations

  • 1 Trauma Center, Peking University People's Hospital, Key Laboratory of Trauma and Neural Regeneration, Ministry of Education, Peking University, National Center for Trauma Medicine, Beijing, 100044, PR China.
  • 2 State Key Laboratory of Organic-Inorganic Composites, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing, 100029, PR China.
  • 3 School of Medicine, South China University of Technology, Guangzhou, 510006, PR China.
  • 4 Laboratory Animal Unit, Peking University, People's Hospital, Beijing, 100044, PR China.
  • 5 Department of Vascular Surgery, Peking University People's Hospital, Beijing, 100044, PR China.
PMID: 40538763 DOI: 10.1016/j.bioactmat.2025.05.034
Abstract

Wound healing remains a critical clinical challenge due to inflammatory responses, oxidative stress in the wound microenvironment, and impaired tissue remodeling. In this study, an anisotropic scaffold was developed by integrating photothermal stimulation with topographical cues to modulate wound healing. The scaffold consisted of gelatin methacryloyl (GM) hydrogel and radially aligned poly (ε-caprolactone) (PCL) fibers integrated with polydopamine (PDA). The anisotropic scaffold not only exhibited anti-inflammatory effects but also enabled localized thermal stimulation under near-infrared (NIR) light to promote wound healing. It guided cell migration and proliferation from the wound edge toward the center, while the GM hydrogel maintained a moist environment and mitigated uncontrolled thermal damage. In a full-thickness skin wound model in rats, the anisotropic scaffold accelerated wound healing, epidermal regeneration, angiogenesis, and Collagen deposition. This approach offers a safe, efficient, and bioactive-factor-free therapeutic strategy for wound repair, showing great potential for clinical translation.

Keywords

Cell migration; Mild heat stimulation; Near-field electrospinning; Radially aligned fibers; Wound healing.

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