1. Academic Validation
  2. Intrapleural pressure-controlled piezo-catalytic nanozyme for the inhibition of malignant pleural effusion

Intrapleural pressure-controlled piezo-catalytic nanozyme for the inhibition of malignant pleural effusion

  • Nat Commun. 2025 Apr 3;16(1):3194. doi: 10.1038/s41467-025-58354-9.
Zihan Xu # 1 2 3 Xiujing He # 1 Yu Gui # 1 Lingkai Tang # 4 Yuxin Zhao 5 Linlin Song 1 Tianyue Xu 1 Meixu Chen 1 Yujie Zhao 1 Peixin Du 1 Xin Wang 1 Siyi Chen 6 Yong Luo 2 7 Feng Luo 2 3 Huan Meng 8 Jianping Hu 4 Wei Zhuo 9 10 Jing Jing 11 Hubing Shi 12
Affiliations

Affiliations

  • 1 Institute of Breast Health Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, Sichuan, China.
  • 2 Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
  • 3 Lung Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
  • 4 Key Laboratory of Medicinal and Edible Plants Resources Development of Sichuan Education Department, School of Pharmacy, Chengdu University, Chengdu, Sichuan, China.
  • 5 Department of Ultrasound, the Affiliated Hospital of Southwest Jiaotong University, the Third People's Hospital of Chengdu City, Chengdu, Sichuan, China.
  • 6 Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
  • 7 Yingshan Hospital, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
  • 8 CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing, China.
  • 9 Department of Colorectal Surgery and Oncology, Center for Medical Research and Innovation in Digestive System Tumors, Ministry of Education, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. wzhuo@zju.edu.cn.
  • 10 Department of Cell Biology, Center for Medical Research and Innovation in Digestive System Tumors, Ministry of Education, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. wzhuo@zju.edu.cn.
  • 11 Institute of Breast Health Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, Sichuan, China. jingjing@wchscu.cn.
  • 12 Institute of Breast Health Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, Sichuan, China. shihb@scu.edu.cn.
  • # Contributed equally.
Abstract

Malignant pleural effusion (MPE), persistently generated by thorax tumor cells at the advanced stage, remains a major challenge for Cancer therapy. Herein, we develop an ultra-sensitive piezoelectric nano-system by doping ytterbium in metal-organic framework (O3P@LPYU), which can be triggered by physiological intrapleural pressure during breath. Under the gently alterative pressure, the piezoelectric nanoparticles with notable peroxidase-like activity effectively produce a burst of Reactive Oxygen Species and induce immunogenic cell death by catalysis of carried ozone as well as peroxide in interstitial fluid. A clear and sustained biodistribution is observed in thorax effusion and tumors upon intrapleural administration of particle. Remarkably, due to the abundant substrates in oxygen-rich environment of pleural cavity, O3P@LPYU particle provides a potent reduction of MPE volume and durable inhibition of tumor growth in thorax. Our work not only develops a bio-responsive piezoelectric nano-system, but also provides a strategy for persistent suppression of MPE in clinics.

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